In the past two decades it has become clear that in addition to antigen presentation and antibody production B cells play prominent roles in immune regulation. While B cell-derived IL-10 has garnered much attention, B cells also effectively regulate inflammation by a variety of IL-10-independent mechanisms. B cell regulation has been studied in both autoimmune and inflammatory diseases. While c...

Many small lymphocytes in mouse bone marrow display surface IgM molecules and receptors for Fc and complement (1-3). Cytocentrifuge rosetting studies demonstrate well-defined Fc and complement receptors on certain marrow small lymphocytes, but the incidence of these cells relative to IgM-bearing lymphocytes is lower than in the peripheral lymphoid tissues (1, 2). These findings suggest that the...