Here we describe a case of infective endocarditis caused by Tropheryma whipplei in a patient with no other symptoms of Whipple's disease. The case was diagnosed using broad-range PCR and confirmed by specific PCRs. We review the cases of infective endocarditis presenting as the only manifestation of Whipple's disease reported in the literature.

Lactococcus garvieae is considered a rare, opportunistic pathogen with low virulence in human infection. There are only scattered case reports of L. garvieae-related infection in humans in the past 20 years. The majority of them were reported to be infective endocarditis. We present a case study of a 41-year-old man with infective endocarditis caused by L. garvieae which is the first reported c...

This paper argues that the National Institute for Health and Clinical Excellence should not offer guidance in situations where there is insufficient evidence equipoise about the potential benefit of the treatment in question. This is broadly for two reasons. First, without knowing if the treatment is effective no cost-effectiveness judgement can be logically made. Second, the implementation of ...

These guidelines have been produced following a literature review of the requirement for prophylaxis to prevent bacterial endocarditis following dental and surgical interventions. Recommendations are made based on the quality of available evidence and the consequent risk of morbidity and mortality for "at risk" patients.

BACKGROUND Antibiotic prophylaxis recommendations for the prevention of infective endocarditis are based in part on studies of bacteremia from dental procedures, but toothbrushing may pose a greater threat. The purpose of this study was to compare the incidence, duration, nature, and magnitude of endocarditis-related bacteremia from single-tooth extraction and toothbrushing and to determine the...

pREVIOUS reports from this laboratory have described an effective method of producing impairment of cardiac lymph flow in the dog.1-3 One of our dogs, operated upon to produce chronic impairment of cardiac lymph flow, died spontaneously 82 days after surgery. A mediastinal abscess and a vegetative endocarditis of the mitral valve were found at autopsy. The valve changes being a unique occurrenc...

The role of dextran in the pathogenesis of bacterial endocarditis was investigated by studying the adherence of dextran producing oral streptococci to the constituents of nonbacterial thrombotic endocarditis (NBTE) in vitro and in vivo. The adherence of Streptococcus sanguis to fibrin and platelets was determined in an in vitro assay system simulating nonbacterial thrombotic endocarditis. Adher...

T HE purpose of this report is to describe the successful treatment of a case of bacterial endocarditis due to Brucella abortus. As far as I have been able to discover at the date of writing, no successfully treated case of this disease has been reported previously, with the exception of a case of mixed bacterial endocarditis presented in 1954 by Quinn and Brown.' A second case of treated Br. a...