نتایج جستجو برای: bacterial sepsis
تعداد نتایج: 243456 فیلتر نتایج به سال:
INTRODUCTION Differentiating between sterile inflammation and bacterial infection in critically ill patients with fever and other signs of the systemic inflammatory response syndrome (SIRS) remains a clinical challenge. The objective of our study was to mine an existing genome-wide expression database for the discovery of candidate diagnostic biomarkers to predict the presence of bacterial infe...
BACKGROUND: Canine low-dose sepsis model provides a reliable setting to study innovative drugs. Lipopolysaccharides (LPS), a major constituent of bacterial outer membrane, have been demonstrated to play a critical role in the initiation of pathogenesis. Lipopolysaccharide-induced sepsis has been extensively studied in laboratory animals; but its importance has mainly remained unknown in dogs. ...
ISSN 2041-6792 10.4155/CLI.10.19 © 2011 Future Science Ltd Despite advances in critical care, the incidence and mortality from severe sepsis remains unacceptably high. Numerous strategies focusing on the pathophysiology of severe sepsis are being pursued. Bacteria and bacterial products that trigger sepsis are being targeted via antibodies, signaling antagonists and filtration columns. Excessiv...
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Alveolar macrophages (AM) have been implicated in the polymorphonuclear leukocyte (PMN) recruitment to the lungs during sepsis. Using an in vivo murine model of sepsis (feces in the peritoneum), we show that peritonitis leads to increased activation of AM and PMN migration into pulmonary alveoli. To assess cellular mechanisms, an in vitro construct of the pulmonary vascular-interstitial inter...
Thrombomodulin (TM), a widely expressing glycoprotein originally identified in vascular endothelium, is an important cofactor in the protein C anticoagulant system. TM appears to exhibit anti-inflammatory ability through both protein C-dependent and -independent pathways. We presently have demonstrated that recombinant N-terminal lectinlike domain of TM (rTMD1) functions as a protective agent a...
The complement system plays an important role in the initial defense against Neisseria meningitidis. In contrast, uncontrolled activation in meningococcal sepsis contributes to the development of tissue damage and shock. In a novel human whole blood model of meningococcal sepsis, we studied the effect of complement inhibition on inflammation and bacterial killing. Monoclonal antibodies (mAbs) b...
Various coagulation tests like Prothrombin Time (PT) and Activated Partial Thromboplastin (APTT) are estimated by automated analyzers. The newer fully analyzers generate clot wave forms aPTT-CWA for these parameters derived. In this study, the objective was to analyze form characteristics morphology its first second derivative values in cases with abnormal APTT. ACL TOP 300 generated curves APT...
Neonatal sepsis is a common cause of neonatal morbidity and mortality in developing countries. It is a serious bacterial infection of blood with a clinical syndrome characterized by systemic signs of infection and bacteremia in the first month of life. Factors associated with positive blood culture and perinatal deaths among neonates are rarely described in developing countries. This study aime...
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