The in vitro bactericidal activity of cefazolin was found to be similar to that of cephaloridine and cephalothin but slightly greater than that of cephalexin against a majority of 233 strains of gram-positive and gram-negative organisms. Cefazolin, however, was two- to eightfold more active than the other two drugs against Escherichia coli and klebsiella. The mean peak concentrations in the ser...

During routine addition of penicillinase (beta-lactamase) to patients sera, we found that the capacity of some of these sera to kill serum-sensitive gram-negative organisms was significantly decreased. Further controlled studies showed that penicillinase decreased both the bactericidal activity of normal human sera and the total hemolytic activity (CH50) of complement in these sera. The decreas...

This study evaluated the antimicrobial, antioxidant and toxicity activity of essential oils (EOs) Hymenaea courbaril L. var. bark Syzygium cumini (L.) Skeels leaves. The EOs were extracted by hydrodistillation chemically characterized gas chromatography coupled to mass spectrometry (GC/MS). ABTS DPPH assay used evaluate activity. For assay, lethality was against Artemia salina Leach. antimicrob...