MicroRNAs (miRNAs) are short RNA molecules that regulate gene expression by binding to target messenger RNAs and by controlling protein production or causing RNA cleavage. To date, functions have been assigned to only a few of the hundreds of identified miRNAs, in part because of the difficulty in identifying their targets. The short length of miRNAs and the fact that their complementarity to t...

While NASA’s current next-generation launch vehicle research has largely focused on advanced allrocket single-stage-to-orbit vehicles (i.e. the X-33 and it’s RLV operational follow-on), some attention is being given to advanced propulsion concepts suitable for “next-generation-and-a-half” vehicles. Rocketbased combined-cycle (RBCC) engines combining rocket and airbreathing elements are one cand...

Parkinson’s disease is one of the most common movement disorders characterized by bradykinesia, rigidity, resting tremor and postural instability (Fahn, 2003). It affects nearly five million elderly people worldwide (de Lau & Breteler, 2006). As the population ages, the incidence and prevalence of Parkinson’s disease are expected to increase dramatically (Dorsey et al., 2007; Tanner & Goldman, ...

sionals that we will need? Factors affecting the health workforce. Washington, DC: Association of Academic Health Centres, 2006. 2 Toffler A. Future shock. New York: Bantam Books, 1970. 3 Carroll F. A Harvard doctor doing research at the lab hopes to market a new way to remove acne and body fat.Daily Press 13 Apr 2006; A: 1. 4 Grenda E. Castle Island’s worldwide guide to rapid prototyping. Medi...

Background: Most patients with MCL, a rare B-cell non-Hodgkin lymphoma, will relapse or become refractory to treatment. While the introduction of BTKis has been transformative, options for who fail respond whose disease progresses on remain limited and largely palliative in nature. We sought characterize quantify unmet clinical need R/R MCL post-BTKi setting. Methods: MEDLINE, Embase, CENTRAL w...

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