Using selective cytochrome P450 (CYP) inhibitors and clinical concentrations (4 microM) of dapsone (DDS), we found a major contribution of CYP2C9 and little or no contribution (< or = 10%) of CYP3A4 and CYP2E1 to dapsone N-hydroxylation (DDS-NHY) in human liver microsomes. Sulfaphenazole (2.16 microM) and tolbutamide (500 microM), selective inhibitors of CYP2C9 (or 2C8/9), inhibited DDS-NHY by ...

1 DDS, Resident Fellow in Removable Partial Dentures, Faculty of Dental Medicine, University of Monastir, Tunisia. 2 DDS, Professor in Histology and Embryology, Faculty of Dental Medicine, University of Monastir, Tunisia. 3 DDS, Assistant Professor in Removable Partial Dentures, Faculty of Dental Medicine, University of Monastir, Tunisia. 4 DDS, Professor in Removable Partial Dentures, Faculty ...

We describe decomposition during search (DDS) as a novel search algorithm for counting the solutions of a CSP. DDS enhances standard tree search by dynamically decomposing sub-problems into independent problems, avoiding redundant work. The paper provides formal definitions and analysis of the introduced method. We integrate DDS into a modern constraint programming system, using Gecode as an ex...

High-performance data analytics (HPDA) is a current trend in e-science research that aims to integrate traditional HPC with recent analytic frameworks. Most of the work done this field has focused on improving frameworks by implementing their engines top technologies such as Message Passing Interface. However, there lack integration from an application development perspective. workflows ...

If Decision Diagrams (DDs) are used for the representation of the logical behavior of a combinational logic circuit it has to be traversed in topological order. At each gate the corresponding synthesis operation is carried out. This traversal process is called symbolic simulation. Obviously the sequence in which the operations are performed at each gate innuences the number of nodes needed duri...

Bond strength evaluation of self-etch and total-etch adhesive systems on intact and ground human enamel Marina Di Francescantonio Marcelo Tavares de Oliveira Mirela Sanae Shinohara Gláucia Maria Bovi Ambrosano Marcelo Giannini DDS, Graduate student (Master degree), Department of Restorative Dentistry DDS, MSc, Graduate student (Doctor degree), Department of Restorative Dentistry DDS, MSc, PhD, ...

Objective: To evaluate the relation between diabetes-related distress and the clinical and sociodemographic characteristics of type 2 diabetes mellitus patients. Methods: A cross-sectional study based on a secondary analysis of data collected at a specialized care outpatient center in Brazil. Participants completed a questionnaire on sociodemographic and clinical characteristics and the Brazi...

Approaches to residential development have clear effects on the surrounding environments, including those on habitat protection, water quality, transportation and congestion costs, and loss of public open space. Ecological subdivision designs (ESDs) are a means to mitigate some of the most negative effects of low-density dispersed landuse patterns, yet there is not widespread adoption of these ...

This paper proposes a method to generate program code for embedded systems using Multi-valued Decision Diagrams (MDDs) that are called heterogeneous MDDs. The heterogeneous MDDs represent logic functions more compactly, and have shorter average path length than other Decision Diagrams (DDs). The code generated using heterogeneous MDDs can evaluate logic functions faster using a small amount of ...