The process by which IT competencies are created and applied to develop firm specific IT resources is not well understood. Previous research on the phenomenon has operated from the resource-based view (RBV); however, conceptual problems with resource-based theory have neither been noted nor addressed by IS researchers. This study acknowledges these problems and provides a solid conceptual found...

The resource-based view (RBV) ascribes superior firm performance to firm resources and capabilities. In recent years, much debate about the value of e-business has been raised because of the costly investments required. Although studies have found positive relationships between e-business and firm performance, there is a need to further investigate into these topics. Since innovation has become...

BACKGROUND Eradication of hepatitis C virus (HCV) using direct-acting agents (DAA) has been associated with a financial burden to health authorities worldwide. We aimed to evaluate the guideline-based treatment costs by DAAs from the perspective of the Brazilian Ministry of Health (BMoH). METHODS The activity based costing method was used to estimate the cost for monitoring/treatment of genot...

BACKGROUND A multinational trial (APRICOT) showed that peginterferon alfa-2a (40kDa) plus ribavirin is efficacious for treatment of HIV-HCV co-infection. The cost-effectiveness of treating these patients with peginterferon alfa-2a/ribavirin has yet to be explored from a US societal perspective. OBJECTIVE To predict the cost-effectiveness of peginterferon alfa-2a/ribavirin with interferon/riba...

This research has two main objectives. Firstly, this research contributes to defining the concept of export entrepreneurship from a theoretical point of view, and this is a contribution taking into account the scarce and fragmented literature published about this topic. Furthermore, the authors explain export entrepreneurship dimensions – speed, degree, and scope. Thirdly, we empirically analyz...

BACKGROUND/OBJECTIVE Genetic polymorphisms in the inosine triphosphatase (ITPA) gene have been associated with the protection from early ribavirin(RBV)-induced hemolytic anemia among patients with chronic hepatitis C virus (HCV) infection. The aim of the present study was to investigate the association between the functional ITPA variants and hematological side effects during antiviral therapy ...

UNLABELLED Two functional variants in the inosine triphosphatase (ITPA) gene causing inosine triphosphatase (ITPase) deficiency protect against ribavirin (RBV)-induced hemolytic anemia and the need for RBV dose reduction in patients with genotype 1 hepatitis C virus (HCV). No data are available for genotype 2/3 HCV. We evaluated the association between the casual ITPA variants and on-treatment ...

Industry 4.0 technologies and technological concepts can be considered as a starting point to strengthen the long-term competitiveness of modern enterprises. In this context, only handful recent studies consider importance professional 4.0-driven servitization and, therefore, investigate causal relationship between company performance. This paper aims preliminary scrutinize set influencing fact...

PURPOSE Chronic Hepatitis C Virus (HCV)-infected patients with liver cirrhosis (LC) respond poorly to interferon-alpha (IFN-α) and ribavirin (RBV) combination therapy, but the reason for this is unclear. We previously reported that HCV-infection induces endoplasmic reticulum (ER) stress and autophagy response that selectively down regulates the type I IFN-α receptor-1 (IFNAR1) and RBV transport...

BACKGROUND We used a Monte Carlo computer simulation to estimate the effectiveness and cost-effectiveness of screening for acute hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-infected men who have sex with men. METHODS One-time screening for prevalent HCV infection was performed at the time of enrollment in care, followed by either symptom-based screening, screening ...