Psoralen ultraviolet A (PUVA) is a proven modality in dermatological therapeutics. It is widely practiced in the treatment of psoriasis, vitiligo, atopic eczema, certain skin cancers, photosensitivity dermatoses, alopecia areata, graft-versus-host disease and morphea.1-3 In presence of UVA, psoralen intercalates between the DNA base pairs forming functional adducts, free radicals and reactive o...

mucinous material in the dermis. As regards therapy, LM is very dif® cult to treat. Various agents have been tried, including melphalan, prednisone, cyclophosphamide, clorambucil, radiation, PUVA, plasma exchange, 2-chlorodeoxyadenosine, isotretinoin, photophoresis and interferon-a. None of these agents has been universally effective and many are associated with signi® cant toxicity. Our patien...

Hypopigmented mycosis fungoides is a rare variant of the cutaneous T-cell lymphoma, in which hypopigmented lesions are seen without the classical lesions. Only three cases are found in the Latin-American literature. We report the case of a 29-year-old black male patient, who first presented with these lesions 20 years ago. The treatment is similar to the classical forms of the disease: psoralen...

The occurrence of bullous pemphigoid (BP) in patients with psoriasis has occasionally been reported. Most previously reported cases attributed the occurrence of BP in psoriasis to photochemotherapy, such as PUVA, UVA and UVB (1–4). We describe here a patient who initially had psoriasis vulgaris and subsequently developed BP after treatment with UVA for psoriasis. Histopathologic, direct immunof...

Even before the recent development of biological agents, a long list of effective treatments has been available for patients with psoriasis. Topical therapies such as corticosteroids, vitamin D analogues, and retinoids are used for localised disease. Phototherapy including broadband ultraviolet B (UVB), narrowband UVB, PUVA, and climatotherapy are effective for more extensive disease. Systemic ...

Scleredema is a rare condition of unknown pathogenesis. It is classically divided into three types, based on its association with postinfection (usually streptococcal), monoclonal gammopathy and diabetes mellitus (scleredema diabeticorum). Scleredema diabeticorum often has a subtle onset, persistent involvement and is refractory to therapies. Numerous therapies have been tried, with mixed and i...