BACKGROUND Adverse reactions induced by BCG vaccination are rare, disseminated mycobacterial BCG infection in particular, which is often fatal and results from impaired immunity. The aim of this study is to determine the nature of the immunodeficiences in patients with disseminated BCG infection in northwest region of Iran. MATERIALS AND METHODS Through 2 years all infants with BCG adenitis o...

A tuberculosis vaccine candidate consisting of a 72-kDa polyprotein or fusion protein based upon the Mtb32 and Mtb39 antigens of Mycobacterium tuberculosis and designated Mtb72F was tested for its protective capacity as a potential adjunct to the Mycobacterium bovis BCG vaccine in the mouse and guinea pig models of this disease. Formulation of recombinant Mtb72F (rMtb72F) in an AS02A adjuvant e...

OBJECTIVES To critically assess the prevalence among schoolchildren 6 to 9 years of age throughout the Dominican Republic of a bacille Calmette-Guérin (BCG) vaccination scar, and to examine the relationship between nutritional and sociodemographic factors and the likelihood of having a BCG scar. METHODS This correlational study used the database of the Second National Census on Height and Wei...

Intravesical Mycobacterium bovis BCG instillation therapy is commonly used to prevent recurrences of carcinoma in situ (CIS) and/or Ta/T1 papillary tumors of the urinary bladder (8). A rare and serious complication associated with BCG treatment of bladder cancer is the development of disseminated BCG disease (1, 6). Current recommendations for bladder cancer patients (being treated with BCG) wh...

Non-muscle invasive bladder cancer (NMIBC) is a common urological malignancy, and bacillus Calmette-Guérin (BCG) therapy the gold standard treatment in intermediate high-risk groups. However, BCG failure occurs significant proportion of patients, emphasizing need for effective alternative modalities to address this burden. These treatments include immunotherapy, enhanced drug delivery, targeted...

Abstract In recent decades ballistocardiography (BCG) has regained popularity as a way to measure the mechanical activ- ity of heart. this paper we present and evaluate new iteration our mobile BCG measurement system. The pro- posed system uses an inertial unit (IMU) placed on carotid artery derive BCG. We conducted mea- surement series do initial in- vestigation into whether more complex heart...

Intravesical Bacillus Calmette Guerin (BCG) immunotherapy is the standard initial therapy for patients with high-grade urothelial bladder cancer without muscle invasion. While minor complications due to intravesical BCG immunotherapy are common, cutaneous infections of the glans penis are quite rare. Granulomatous balanitis can be devastating if not identified and treated early. A well-establis...

A prime-boost strategy conserving BCG is considered the most promising vaccine to control tuberculosis. A boost with a DNA vaccine containing the mycobacterial gene of a heat shock protein (pVAXhsp65) after BCG priming protected mice against experimental tuberculosis. However, anti-hsp65 immunity could worsen an autoimmune disease due to molecular mimicry. In this investigation, we evaluated th...