Biosimilars of biologics used for cancer treatment and supportive care are expected to enter the U.S. market soon. Biosimilars will be highly similar to their reference products, but unlike generic drugs, not identical. Differences between a biosimilar and its reference product may arise because of the complexity of biologics, and differences in the cell lines and processes used during manufact...

The communication of chemistry to wider society is difficult because of ‘chemophobia’, its inherent complexity and its lack of unifying grand themes. To engage with citizens about the benefits and related dangers of the field, chemists must improve their dialogue with broader sections of the public — but how?

For a typical software system, it is generally considered infeasible to calculate system reliability from the reliabilities of its constituent components because software systems, unlike hardware systems, tend to violate the underlying independence assumptions inherent in the usual reliability calculations. In this paper, we present new method for calculating the system reliability from its con...

In the last ten years, field and object models have emerged as two opposing approaches for conceptualizing and modeling geographic phenomena. In the context of a field perspective, each point in space is mapped to a value selected from an attribute domain. In this way, geographic space is perceived as 'full', as every location is occupied by a value. In the context of an object perspective, spa...

The hybrid signcryption scheme based on certificateless public key cryptography avoids the complexity of certificate management existing in the traditional public key cryptography and the inherent key escrow problem existing in identity-based public key cryptography. The certificateless hybrid signcryption scheme combined with certificateless signcryption key encapsulation mechanism and data en...

Writers are often viewed as having an inherent style which can serve as a literary fingerprint. By quantifying relevant features related to literary style, one may hope to classify written works and even attribute authorship to newly discovered texts. Beyond its intrinsic interest, the study of literary styles presents the opportunity to introduce and motivate many standard multivariate statist...

Data cleansing is a process that deals with identification of corrupt and duplicate data inherent in the data sets of a data warehouse to enhance the quality of data. This paper aims to facilitate the data cleaning process by addressing the problem of duplicate records detection pertaining to the „name‟ attributes of the data sets. It provides a sequence of algorithms through a novel framework ...

Facilities for complex object modeling are nowadays needed in several areas of database applications (CAD/CAM, office automation, robotics, ...). Consequently, either new models are developed, or existing ones (relational, functional) are extended to better respond to this requirement. This paper intends to show that the entity-relationship approach may offer the required facilities, preserving...

As is well known, attribute reduction is one of the basic concepts in rough set theory. In this paper, a new algorithm for computing equivalence classes based on segment quick sort is provided and its time complexity is cut down to O(|C||U|) compared with traditional algorithms. Then a method for computing object number of positive region without computing positive region is given. On this basi...

determinism  and debility (wahn) reputation to preceding lawyers hossein bahrami aghdam [1]   abstract determinism and traditional documentary-brokerage debility (wahn) currently signify a special attribute, and in inference it is unique. however, the attitudes of ancients themselves concerning that attribute and evaluation of its reliablity was determinant. in research and re-reading of works ...