Cancer's cellular behavior is driven by alterations in the processes that cells use to sense and respond to diverse stimuli. Underlying these processes are a series of chemical processes (enzyme-substrate, protein-protein, etc.). Here we introduce a set of mathematical techniques for describing and characterizing these processes.

Muscles and tendons are highly adaptive tissues in response to chronic changes in loading and to aging. A remarkable reorganization in muscle architecture occurs in both conditions together with significant alterations in tendon mechanical properties. This review discusses the possible mechanisms underlying these myotendinous changes and the influence thereof on the behavior of the muscle-tendo...

Introduction Patients with systemic lupus erythematosus (SLE) have cognitive dysfunctions as a neuropsychiatric manifestation, associated disabling symptoms. However, the presence of other medical or psychiatric comorbidities can delay lead to misdiagnose. Objectives To present case patient diagnostic difficulty in face multiple and neurocognitive comorbidities. Methods Description report. Resu...

UNLABELLED Evidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear, and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA administration of the GABA(A) receptor agonist muscimol on the expression of conditioned-fear, formalin-evoked nociception, and fear-conditioned analgesia in rats, an...

Stress during childhood and adolescence enhances the risk of psychopathology later in life. We have previously shown that subjecting male rats to stress during the peripubertal period induces long-lasting effects on emotion and social behaviors. As corticosterone is increased by stress and known to exert important programming effects, we reasoned that increasing corticosterone might mimic the e...