Background and Aims: Prostate cancer (PCa) is one of the most common cancers among men in Iran. Since changes in the regulation of proto-oncogenes expression are the main causes of most human cancers, including PCa, evaluating the expression of marker genes can be helpful for early diagnosis of cancer and better understanding of its etiology. The present study compared c-Myc expression level in...

Prostate cancer is the second most commonly diagnosed malignancy in men worldwide. The prevalence has been increasing with significant differences between regions. This study assesses of incidental prostate detected specimens removed during bladder outlet obstruction operation. A retrospective analysis records patients who had either endoscopic or open prostatectomy from January 1998 to Decembe...

OBJECTIVE To assess whether Free/Total prostate specific antigen (PSA) would enhance prostate cancer detection in men with total serum PSA between 2.5 and 10 ng/ml. METHODS This case control study was conducted in the Department of Urology and Renal Transplantation, Jinnah Hospital, Lahore from January 2001 to June 2004. A total of 200 consecutive patients with symptoms of prostate disease, a...

AIM OF THE STUDY Recent investigations have taken into account the role of mast cells in prostate cancer formation, analyzing their dual functions (as tumour growth promoters and tumour growth inhibitors). The aim of our study was to compare mast cell infiltration and microvessel density in prostate cancer and in benign prostate hyperplasia. We also attempted to find possible relationships amon...

The present study investigated the role of androgen in the process of androgen-induced prostate hyperplasia in castrated rats and assessed the role of the phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin (PI3K/Akt/mTOR) pathway in this process. Furthermore, the extent to which autophagy may affect the level of androgen-induced benign prostatic hyperplasia was also expl...

Objective: Exploring the clinical efficacy of transurethral plasma enucleation prostate in treatment benign prostatic hyperplasia with underactive bladder detrusor contractility. Methods: Retrospective analysis data 68 patients and muscle contractility treated by our department from July 2021 to 2022. The above all met diagnosis hyperplasia, excluding cancer urethral stricture. Urodynamics show...

Holmium laser enucleation of the prostate (HoLEP) surgery has been increasingly used in urology because its advantages for benign prostatic hyperplasia (BPH) surgical treatment recent years. But, there are insufficient data literature about true frequency incidental presence adenoma within bladder following HoLEP surgery. The case is here presented a patient who underwent 5 years previously, th...

The aquaporin (AQP) families of water channels are intrinsic membrane proteins that facilitate selective water and small solute movement across the plasma membrane. The purposes of this study were to determine the expression and localization of AQPs in benign prostatic hyperplasia and prostate cancer. Prostatic tissue was collected from patients with benign prostatic hyperplasia or prostate can...

background: estimating prostate volume using less invasive transabdominal ultrasonography (taus) instead of transrectal ultrasonography (trus) is of interest in terms of identifying their agreement level. previous reports on this subject, applied general correlation coefficient as the level of agreement. this study uses bland-altman method to quantify taus and trus agreement on estimating prost...

Prostate-specific antigen (PSA) is the one of the most valuable tumor markers for the early detection and management of prostate carcinoma, but not an ideal one because of poor specificity in the case of prostatic hypertrophy and other benign conditions. In order to overcome this drawback some other parameters as is free to total ratio (F/T) PSA and PSA density (PSAD) are introduced. It has bee...