In the present work, we have applied group quantitative structure–activity relationships (G-QSAR) for exploring the relationship between the structures of a new emerging family of 2-{[2-(1Himidazol-1-yl)ethyl]sulfanyl}-1H-benzimidazole derivatives and their antiprotozoal activities. We have developed descriptive models, in order to aid in further optimization and development of newer antiprotoz...

The reactions of the benzimidazole nitrogen atoms and the exocyclic amino group of 2-aminobenzimidazole with CS2 in NaOH basic medium followed by methylation with methyl iodide was explored. With careful control of the stoichiometric quantities and addition sequences, this set of reactions allows the selective functionalization of the benzimidazole ring with N-dithiocarbamate, S-methyldithiocar...

A straightforward method has been developed for the synthesis of the benzimidazole ring system through a carbon-nitrogen cross-coupling reaction. In the presence of 2.0 equiv. of K(2)CO(3) in water at 100 °C for 30 h, the intramolecular cyclization of N-(2-iodoaryl)benzamidine provides benzimidazole derivatives in moderate to high yields. Remarkably, the procedure occurs exclusively in wat...

Kết quả nghiên cứu phổ hồng ngoại của DES điều chế cho thấy có sự hình thành tương tác liên kết hydrogen phân tử giữa L-proline và acid para-toluenesulfonic. Điều kiện thực hiện phản ứng tốt nhất thu được sau khi khảo sát: nhiệt độ 80oC, thời gian 120 phút, tỉ lệ benzaldehyde:o-phenylenediamine=2:1 (mmol) lượng xúc sử dụng là 30% mol so với o-phenylenediamine. Xúc thể 4 lần mà không thay đổi ho...

The aim of this review is to provide the systematic information synthetic scheme and biological activity synthesized benzimidazole derivatives. Benzimidazole widely used lead molecule for synthesis various types pharmacologically active moiety. It heterocyclic aromatic fused colorless solid having molecular mass 118.053 g/mol. basic in nature can be served as ligand coordination chemistry. bioa...

A single-site Fe catalyst was prepared from bio-based precursors: xylose and haemoglobin. Its catalytic activity, selectivity, recyclability for nitroarene transfer hydrogenation using isopropanol, benzimidazole preparation, is reported.

The spin transition temperatures of [Fe(didentate)3]2+in acetonitrile (didentate = 2-X-benzimidazole) can be stepwise decreased by 40 K along the series X pyrazine > pyridine pyrimidine.