substituted schiff bases (hydrazones) 5a-j have been prepared from the starting material 2-chloro pyridine-3-carboxylic acid 1 by a sequence of reactions like reaction with 2-amino-6-nitro benzothiazole (ullamann condensation), thionyl chloride, hydrazine hydrate and different aromatic aldehydes. on cyclocondensation of 5a-j with thioglycolic acid in dry 1,4-dioxane furnished desired compounds ...

O vírus Zika (ZIKV) são flavivírus pertencentes à família flaviviridae, que transmitidos pela picada do vetor infectado; nesse caso, mosquito gênero Aedes aegypti. A replicação viral é função da proteína não estrutural NS3-pro atua em associação com NS2B, aumentando a eficiência enzimática. Assim, esse domínio protease N2B-NS3 apresenta um alvo atrativo para o planejamento de novos fármacos ant...

Quaternary 2-thiomethylbenzazoles are important class of intermediates involved in the synthesis of symmetric and asymmetric monomethine cyanine dyes. In addition to, 2methylmercaptobenzothiazole, and 2methylmercaptobenzoxazole derivatives represent an essential group of compounds for the synthesis of cyanine dyes [1–3]. S-Alkylated heterocyclic derivatives are known as key compounds, finding a...

A broad spectrum of organic chemicals is essential to modern society. Once discharged from industrial, domestic and urban sources into the urban wastewater collection system they may transfer to the residual solids during wastewater treatment and assessment of their significance and implications for beneficial recycling of the treated sewage sludge biosolids is required. Research on organic con...