672 www.thelancet.com/neurology Vol 10 August 2011 Since the fi nding that cholesterol-lowering statins could induce T-cell-mediated immune modulation and reverse paralysis in mice with experimental autoimmune encephalomyelitis (EAE), there has been substantial interest in whether this class of drugs is benefi cial in multiple sclerosis. One question that has not been answered is whether a stat...

OBJECTIVE To examine the hypothesis that increases in depression after initiation of treatment with interferon beta-1a for multiple sclerosis can be explained as representing a return to pretreatment levels of depression. DESIGN Level of depression in patients with multiple sclerosis was assessed at 3 time points: 2 weeks before initiation of interferon beta-la treatment, at initiation of tre...

Determining to what extent biophysical characteristics of aggregates affect immunogenicity of therapeutic interferon beta-1b. Three recombinant human interferon beta-1b (rhIFNβ-1b) samples with different levels of aggregates generated by copper oxidation, thermal stress, or left untreated, as well as Avonex(®) drug substance and Betaferon(®) drug product, were injected intraperitoneally in nont...

Abstract Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) infection is a major risk factor for mortality and morbidity in critical care hospitals around the world. Lung epithelial type II cells play role recognition clearance of respiratory viruses as well repair lung injury response to environmental toxicants. Gene expression profiling studies revealed that mouse express several ce...