Quartz crystal microbalance with dissipation (QCM-D) monitoring and atomic force microscopy (AFM) were combined to evaluate the defects created by an ionic liquid anion and a cation in a supported phospholipid bilayer composed of zwitterionic lipids on a silica surface. The cation 1-octyl-3-methyl imidazolium (OMIM(+)) was shown to remove lipids from the bilayer, increase the roughness to appro...

Liposomes are widely used as drug delivery systems in different forms including osmotic pumps, infusion and IV injection. In spite of these, there is no data available about their behavior under convective flow (e.g. infusion or osmotic pumps) and upon stagnation in such drug delivery systems. As a part of a series of investigations in this area, the present study investigates the effects of vi...

AIM to quantify the extent of counterfeit sildenafil in Indonesia. METHODS the study was conducted in 4 big areas: Jakarta, Bandung, East Java (Surabaya and Malang), and Medan. Sildenafil 100 mg tablets were purchased from pharmacies, drugstores, street peddlers, and 3 Indonesian websites. The outlets were chosen by random sampling in each stratum (type of outlet). Sildenafil tablets purchase...

In this study, an investigate effect of moisture absorption by ranitidine and resinates used to improve stability of ranitidine hydrochloride tablets. Moisture absorption by ranitidine at three different level of relative humidity (RH) has been studied. Percentage of moisture absorption at 22% was low as compared to 57% and 75% RH. To eliminate deliquescent tendency of drug, weak cation-exchang...

AIM OF THE STUDY Development of standardized, synergistic, safe and effective traditional herbal formulations with robust scientific evidence can offer faster and more economical alternatives for the treatment of disease. The main objective was to develop a method of preparation of guggulkalpa tablets so that the tablets meet the criteria of efficacy, stability, and safety. MATERIALS AND METH...

Objectives Prescribing of treatments with dosages involving split tablets is common. Many patients report they have difficulties in dividing the tablets and in following the prescribed treatment. The objective of this study was to examine to what extent dosages involving split tablets are prescribed in Sweden. Methods The dosage text strings were analysed on prescriptions dispensed during one m...

Famotidine is generally employed for the treatment of gastric ulcer. The present study was conducted to fabricate famotidine tablets using various diluents. The binder was incorporated to the formulations in different proportions. Both the dry granulation and direct compression techniques were employed to develop the tablets. Physical evaluation of tablets i.e. tablets hardness, friability, wei...

The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 2(3) factorial design. The effects of the amounts of calcium alginate, HPMC K4M, and Carbopol 943 in bisoprolol fumarate matrix tablets on the properties of bisoprolol fumarate sustained release matrix tablets like drug release a...

Aspirin has been used therapeutically for over 100 years. As the originator and an important marketer of aspirin-containing products, Bayer's clinical trial database contains numerous reports of the pharmacokinetics of various aspirin formulations. These include evaluations of plain tablets, effervescent tablets, granules, chewable tablets, and fast-release tablets. This publication seeks to ex...

OBJECTIVE The prevalence of maternal anaemia remains unacceptably high in developing countries. At the same time, the percentage of women who consume one or more Fe+folic acid (IFA) tablets during pregnancy remains persistently low. The objective of the present study was to identify where, within antenatal care (ANC) programmes, pregnant women falter in obtaining and consuming an ideal minimum ...