The metabolism of sodium 3 alpha,7 beta-dihydroxy-5 beta-cholane-24-sulfonate and sodium 3 alpha,7 beta-dihydroxy-24-nor-5 beta-cholane-23-sulfonate was studied in hamsters. In bile fistula animals these sulfonate analogs of ursodeoxycholic acid were absorbed mainly from the terminal ileum and secreted rapidly into the bile without biotransformation or conjugation. After oral administration, th...

The first objectives of this article are to review the structure, chemistry, and physiology of bile acids and the types of bile acid malabsorption observed in clinical practice. The second major theme addresses the classical or known properties of bile acids, such as the role of bile acid sequestration in the treatment of hyperlipidemia; the use of ursodeoxycholic acid in therapeutics, from tra...

The accessory olfactory system (AOS) guides behaviours that are important for survival and reproduction, but understanding of AOS function is limited by a lack of identified natural ligands. Here we report that mouse faeces are a robust source of AOS chemosignals and identify bile acids as a class of natural AOS ligands. Single-unit electrophysiological recordings from accessory olfactory bulb ...

NAGAKURA, T., SUZUKI, H., MIYAZAKI, Y., OTSUKI, M., GOTo, J., NAMBARA, T. and TOYOTA, T. Determination of 3/3-Hydroxylated Bile Acids in Human Serum and Liver Tissue. Tohoku J. Exp. Med., 1989, 159 (2), 165-166 3/3, 7aDihydroxy-5/3-cholanoic acid (3/3, 7cr-diOH) was detected in serum of 3 patients with intrahepatic cholestasis. 3/3, 7/3-dihydroxy-5/3-cholanoic acid (3/i, 7/3-diOH) appeared in s...

The mechanism of cholestasis (decreased bile flow) induced by taurolithocholate in the isolated perfused hamster liver was investigated. Taurocholate was infused to maintain bile acid output, and sulfobromophthalein (BSP) was administered to establish a BSP transport maximum in bile. The effects of taurolithocholate on bile flow and on the biliary secretion of BSP and bile acid anions were dete...

The effect of pantethine on bile acids and lipids was studied by the washout technique in Wistar female rats fed for four weeks with a 1% cholesterol diet supplemented with 0. 5% cholic acid, either containing or not containing 1% pantethine. Pantethine caused a slight increase in the biliary cholesterol concentration with a significant decrease in the serum cholesterol, ,8-lipoprotein and trig...

We studied the effects of bile acids on inducibility of the transcription factor AP-1 in human colon carcinoma LoVo cells. Firstly, cells were treated with chenodeoxycholic acid and the nuclear extracts from those cells were processed by electrophoretic mobility shift assays to analyze nuclear AP-1 DNA-binding activity. We demonstrated that chenodeoxycholic acid induced AP-1 DNA-binding activit...

The effect of conjugated and unconjugated bile acids on the binding of vitamin B12 to intrinsic factor was investigated. The dihydroxy bile acids (deoxycholic, glycodeoxycholic, taurodeoxycholic, glycochenodeoxycholic, and taurochenodeoxycholic) inhibit the binding of intrinsic factor to vitamin B12 at physiological concentrations. On the other hand, the trihydroxy bile acids (cholic, glycochol...