The development of separate building performance simulation tools has brought about a significant need for the integration of multi-domain simulations that would enable multiple building performance analyses to be conducted from a single building model. Insufficient data integration between the tools and Building Information Modeling (BIM) currently prevents the efficient production of comprehe...

ABSTRACT: Building maintenance is the responsibility of its owner which must use, whenever appropriate, a technician to perform the inspection. A good maintenance depends on the analysis of the anomalies detected during the inspection of the site. Building Information Models (BIM) have revealed themselves as a good tool when it comes to supporting maintenance actions, due to their ability to st...

Other names: BAM, BIM, BIM-alpha6, BIM-beta6, BIM-beta7, BOD, BimEL, BimL HGNC (Hugo): BCL2L11 Location: 2q13 Local order: According to GeneLoc and NCBI Map Viewer, genes flanking BCL2L11 in plus strand direction are: ACOXL 2q13 (acyl-Coenzyme A oxidase-like); PAFAH1P2 2q13 (platelet-activating factor acetylhydrolase, isoform Ib, pseudogene 2). Note: BCL2L11/BIM is a BH3-only protein from the B...

Integration of cell adhesive, survival, and proliferative processes is essential for capillary morphogenesis of endothelial cells (EC) in vitro and vascular development and function in vivo. Unfortunately, the molecular and cellular mechanisms that impact these processes are poorly defined. Here we examined how lack of bim and/or bcl-2 expression impact lung EC function. The absence of bcl-2 or...

Neurons face a changeable microenvironment and therefore need mechanisms that allow rapid switch on/off of their cytoprotective and apoptosis-inducing signaling pathways. Cellular mechanisms that control apoptosis activation include the regulation of pro/antiapoptotic mRNAs through their 3'-untranslated region (UTR). This region holds binding elements for RNA-binding proteins, which can control...

BIM has recently gained ground in developed countries. However, the use of BIM in developing countries including Cameroon is not well-known. In this study, BIM implementation in Cameroon is explored. The research methods used are a pilot study, electronic email surveys and in-depth phone interviews. Altogether, 179 professionals having at least a Master’s Degree in Civil Engineering from the Na...

Building Information Modelling (BIM) has emerged as a powerful technology that creates a central hub for managing building energy and resources at all phases of the building life cycle. Without it, many tools that lack interoperability are used, thus massively under-exploiting the efforts of other building design and management parties; this largely describes the status quo. However, despite th...

miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is prov...

A Building Information Model (BIM) is a powerful concept, since it allows both 2D-drawings and 3D-models of buildings or facilities to be extracted from the same source of data. Compared to a general 3D-CAD model a BIM is a different kind of representation, since it defines not only geometrical data but also information regarding spatial relations and semantics. However, because of the large nu...

The life and death of T cells is controlled to a large extent by the relative amounts of Bcl-2-related proteins they contain. The antiapoptotic protein Bcl-2 and the proapoptotic protein Bim are particularly important in this process with the amount of Bcl-2 per cell dropping by about one-half when T cells prepare to die. In this study we show that Bcl-2 and Bim each control the expression of t...