Ebola virus VP35 inhibits alpha/beta interferon production and functions as a viral polymerase cofactor. Previously, the 8-kDa cytoplasmic dynein light chain (LC8) was demonstrated to interact with VP35, but the functional consequences were unclear. Here we demonstrate that the interaction is direct and of high affinity and that binding stabilizes the VP35 N-terminal oligomerization domain and ...

Nucleotide-binding oligomerization domain 2 (Nod2) pathways are known to interact with Toll-like receptor 2 (TLR2) and TLR4, which are pattern recognition receptors for Candida albicans. We observed that the prevalence of Nod2 polymorphisms was not increased in patients with Candida infections. Candida-induced cytokine production in individuals with Nod2 polymorphisms was unaffected. We conclud...

Febrile infection-related epilepsy syndrome (FIRES) characteristically affects previously healthy children, who experience a sudden and explosive onset of super-refractory status epilepticus preceded by febrile infection accompanied fulminant neurogenic inflammation. FIRES, however, can affect individuals all ages is subcategory new-onset refractory epilepticus. This definition FIRES excludes i...

Amyloid-β (Aβ) is a peptide formed by 39–43 amino acids, heterogenous the length of its C-terminus. Aβ constitutes subnanomolar monomeric component human biological fluids; however, in sporadic variants Alzheimer’s disease (AD), it forms soluble neurotoxic oligomers and accumulates as insoluble extracellular polymeric aggregates (amyloid plaques) brain tissues. The plaque formation controlled z...

Submit Manuscript | http://medcraveonline.com Abbreviations: HIF: Hypoxia Inducing Factor; NLRP: Nucleotide Leucine Rich Protein; ATP: Adenosine Tri Phosphate; TNF α-: Tumor Necrosis Factor Alpha; AKT: Protein Kinase; mTORCMammalian Target of Rapamycin Complex; WNT: Gene Wingless and Protooncogene Integration; MSU: Mono Sodium Urate; PARP: Poly ADP Ribose Polymerase; AIDS: Acquired Immune Defic...

C99 is the transmembrane carboxyl-terminal domain of the amyloid precursor protein that is cleaved by γ-secretase to release the amyloid-β polypeptides, which are associated with Alzheimer's disease. Nuclear magnetic resonance and electron paramagnetic resonance spectroscopy show that the extracellular amino terminus of C99 includes a surface-embedded "N-helix" followed by a short "N-loop" conn...

Expression of genes in the gapA operon encoding five enzymes for triose phosphate interconversion in Bacillus subtilis is negatively regulated by the Central glycolytic genes Regulator (CggR). CggR belongs to the large SorC/DeoR family of prokaryotic transcriptional regulators, characterized by an N-terminal DNA-binding domain and a large C-terminal effector-binding domain. When no glucose is p...