نتایج جستجو برای: binding proteins
تعداد نتایج: 853111 فیلتر نتایج به سال:
Background: Alteration in the protein signatures of functionally immature testicular spermatozoa occurs during their journey through the epididymis. This leads to acquisition of sperm domain specific functions essential for successful fertilization. Epididymal sperm proteins are preferred targets for immunocontraception as well as in elucidating the causes of infertility. The Background of the ...
Theoretical methods, such as molecular mechanics and dynamics, are very useful in understanding differences interactions at the single molecule level. In life sciences, small conformational changes, including substituent modifications, often have a significant impact on function vivo. Changes binding between nucleic acid molecules proteins prime example. this study, we propose strategy to predi...
Abstract Introduction: There is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor (IGF-I) to transduce the signals in different areas of the brain. In this article we aimed at investigating whether the expression of IGF-I receptor and IGF-I binding proteins (IGFBP1) is change...
background: hepatitis c virus (hcv) is a main public health problem causing chronic liver infection and subsequently liver cirrhosis and lethal hepatocellular carcinoma (hcc). vaccination based on hcv capsid proteins has attracted a special interest for prevention of viral infections. the core protein is a basic and evolutionary most conserved protein, which regulates the cellular processes rel...
Protein specific aptamers are highly applicable affinity ligands in different fields of research and clinical applications. They have been developed against various targets, in particular, bio-macromolecules such as proteins. Among human proteins, the coagulation factors are the most attractive targets for aptamer selection and their specific aptamers had valuable characteristics in therapeutic...
Background and Aim: The material is always covered by proteins immediately upon contact with a physiological environment. Hemoglobin is the one of major blood proteins. The interaction between Hemoglobin and ligands such as nanoparticles is very important and may be cause structural changes on Hemoglobin. Materials and Methods: In this work we will address the effects of silver particles on th...
Protein specific aptamers are highly applicable affinity ligands in different fields of research and clinical applications. They have been developed against various targets, in particular, bio-macromolecules such as proteins. Among human proteins, the coagulation factors are the most attractive targets for aptamer selection and their specific aptamers had valuable characteristics in therapeutic...
a three-fold decrease of the in vitro ability of serum proteins to bind naproxen was shown in patients with cirrhosis of the liver compared to healthy individuals. this decrease was caused by quantitative changes in serum proteins in the sera of patients with liver damage. lower doses of naproxen are therefore suggested in the treatment of patients with liver dysfunction.
background: analysis of human cancer serum has revealed the presence of high amounts of hyaluronan (hyaluronic acid, ha) when compared to human normal serum, it is well documented that ha and its receptors, known as hyaladherins (habps) are involved in matrix regulation, cell proliferation, migration and malignant tumour progression. these hyaladherins not only interact with hyaluronan at the m...
Photo-irradiation of PBDA-modified DNA generates a long-lived intermediate that reacts selectively with Lys residues DNA-binding proteins, leading to higher crosslink yields than traditional photo-crosslinkers such as benzophenone and diazirine.
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