THE USE OF FREE SOFTWARES IN PRACTICAL CLASS ABOUT MOLECULAR FILTERS ORAL BIOAVAILABILITY DRUGS. The study of the physical chemical properties to predict oral bioavailability drugs is a widely tool used by researches on Pharmaceutical and Medicinal Chemistry field. Even though it deeply studied subject, complex task teach pharmacy students. Lipinski stablished that molecular weight, lipophilici...

Itraconazole (ITR), an antifungal agent has poor bioavailability due to low aqueous solubility. The present investigation aimed at development of ITR nanoemulsion to enhance its oral bioavailability. ITR nanoemulsion was prepared using Capmul MCM C8 as oil, Pluronic F68 as co-surfactant and Cremophore EL as surfactant using high speed stirring, followed by probe sonication. Nanoemulsion with av...

The candesartan cilexetil belongs to class II of the biopharmaceutical classification system and bioavailability is 15% due to the poor aqueous solubility. The purpose of the study is to improve aqueous solubility by nano technology of solid lipid nanoparticle by solvent evaporation method. Here glyceryl monosterate (lipid), polaxemor 407, tweeen 80 (co-surfactant and surfactant respectively) a...

The objective of this study was to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the oral bioavailability of the poorly water-soluble compound 20(S)-25-methoxydammarane-3β;12β;20-triol (25-OCH3-PPD). Optimized SMEDDS formulations for 25-OCH3-PPD contained Cremophor® EL (50%) as the surfactant, glycerin (20%) as the cosurfactant, and Labrafil® M1944 (30%) as the oil. T...

this study was conducted to evaluate the relative bioavailability value of mn proteinate and mn oxide in broiler chicks. a total of 432 day-old cobb 500 commercial male broiler chicks were randomly distributed into nine treatments with eight replicate pens of six chicks each. in a completely randomized design experiment with a 2×4 factorial arrangement of two manganese sources (proteinate and r...

The fifth framework EU project BORIS (Bioavailability Of Radionuclides In Soils: role of biological components and resulting improvement of prediction models) had three scientific objectives. The first was to improve understanding of the mechanisms governing the transfer of radionuclides to plants. The second was to improve existing predictive models of radionuclide interaction with soils by in...