diazinon is commonly used for pest control in the agricultural fields surrounding freshwater reservoirs. this study was conducted to determine the chronic toxicity of organophosphorous pesticide and its effects on some hematological parameters and biochemical blood plasma profiles of common carp, cyprinus carpio. diazinon was applied at concentrations of 60 and 120î¼g/l preparations in 10, 20 a...

Protein N-terminal acetyltransferase D (NatD, NAA40) that specifically acetylates the alpha-N-terminus of histone H4 and H2A has been implicated in various diseases, but no inhibitor reported for this important enzyme. Based on acetyl transfer mechanism NatD, we designed prepared a series highly potent NatD bisubstrate inhibitors by covalently linking coenzyme A to different peptide substrates ...

artificial fertilizers and mainly organophosphate herbicide are used by farmers to enhance their crop and control pests. in order to investigate the effects of pretilachlore, fingerlings of caspian roach were exposed to a range of concentrations of toxin close to those of estuary for 96 h. due to movement of these fingerlings in a gradient of salinity from freshwater to brackishwater some physi...

Background Obesity is a significant worldwide health problem that linked with mental health. The elucidation of the possible overlapping biochemical mechanism(s) involved in inflammation and oxidative stress imperative to better understand address obesity related metabolic disorders. aim study was investigate associations between inflammatory profiles parameters reflect metabolic, emotional, Gr...

acetic acid has been applied as an efficient catalyst and a green solvent for the two–component condensation reaction consisting of benzaldehyde, 2-amino-benzamide. the advantages of this protocol was excellent yield, short reaction time, mild reaction conditions, higher availability, low costs, more environmentally friendly, lack of need for column chromatography and simple work-up procedure. ...

the reaction of ch₃nh₂ with o₂ on the singlet potential energy surfaces (pes) was carried out using the b3lyp, ccsd(t) and g3b3 theoretical approaches along with 6-311++g(3df,3pd) basis set. the suggested mechanism for the title reaction consists of one pre-reactive complex. from the pre-reactive complex, nine types of products, ch2nh+h2o2, ch3nh+ooh, nh2cho+h2o, ch2nho+h2o, nh3+hcooh, ch2nh+h2...

Programmed -1 translational frameshifting is a process where the translating ribosome shifts the reading frame, which is directed by at least two stimulatory elements in the mRNA-a slippery sequence and a downstream secondary structure. Despite a lot of theoretical and experimental studies, the detailed pathway and mechanism of the -1 frameshifting remain unclear. Here, in order to understand t...

A growing body of evidence suggests that the accumulation of misfolded proteins in brain tissues is a crucial event in the Parkinson’s disease neurodegeneration. Pathogenic mutations may directly induce abnormal protein conformations or compromise the ability of the cellular machinery to detect and degrade misfolded proteins. Although the recent explosion in the rate of discovery of genetic def...

Time series data on biochemical reactions reveal transient behavior, away from chemical equilibrium, and contain information on the dynamic interactions among reacting components. However, this information can be difficult to extract using conventional analysis techniques. We present a new method to infer biochemical pathway mechanisms from time course data using a global nonlinear modeling tec...

The transient kinetic behaviour of an open single enzyme, single substrate reaction is examined. The reaction follows the Van Slyke-Cullen mechanism, a spacial case of the Michaelis-Menten reaction. The analysis is performed both with and without applying the quasi-steady-state approximation. The analysis of the full system shows conditions for biochemical pathway coupling, which yield sustaine...