INTRODUCTION: Poly(ether-ether-ketone) (PEEK) is considered to be promising novel polymer biomaterial for orthopaedic and spinal applications, because PEEK exhibits excellent mechanical properties, chemical stability, non-magnetic nature, and compatible with reinforcing agents such as carbon fibers, as compared with polyethylene or metallic materials. However, since conventional PEEK cannot sat...

There is an ever increasing need to find surfaces that are biocompatible for applications like medical implants and microfluidics-based cell culture systems. The biocompatibility of five different surfaces with different hydrophobicity was determined using gene expression profiling as well as more conventional methods to determine biocompatibility such as cellular growth rate, morphology and th...

Carbon nanomaterials are being produced in increasingly larger quantities for many applications due to their novel characteristics such as enhanced thermal, electrical, mechanical, and biological properties. However, there is a lack of data on biological interactions to assess their biocompatibility before they will be accepted as non-toxic in industrial or biomedical arenas. In the present stu...

This study aimed to evaluate by the intra-osseous implant technique the most commonly used materials for pulp therapy in pediatric dentistry: calcium hydroxide (CH), Guedes Pinto paste and CTZ paste, according to FDI (1980) and ANSI/ADA (1982) recommendations. Thirty guinea pigs, 10 for each material, divided into experimental periods of 4 and 12 weeks received one implant on each side of the l...

Poly(methyl methacrylate) (PMMA) bone cement has limited biocompatibility. Polycaprolactone (PCL) electrospun nanofiber (ENF) has many applications in the biomedical field due to its excellent biocompatibility and degradability. The effect of coating PCL ENF on the surface topography, biocompatibility, and mechanical strength of PMMA bone cement is not currently known. This study is based on th...

We have prepared Chinese traditional herb Bletilla striata into microspheres as a novel embolic agent for decades. The aim of this study was to evaluate the biocompatibility of Bletilla striata microspheres (BSMs). After a thermal test of BSMs in vitro, the cell biocompatibility of BSMs was investigated in mouse fibroblasts and human umbilical vein endothelial cells using the methyl tetrazolium...

AIM To examine the biocompatibility of two commercial forms of mineral trioxide aggregate (MTA), by evaluating the morphology of an established cell line. METHODOLOGY The two cements were cast on glass cover slips and cured for 1 or 28 days. Saos-2 osteosarcoma cells were trypsinized and seeded at a density of 1 x 10(5) cells and were then placed in medium over the material-coated coverslips ...

Since introduction to the clinics in the 1990s, resorbable osteosynthesis systems have undergone extensive improvements in order to establish their use as a standard treatment, especially in craniomaxillofacial surgery. However, the development of osteosynthesis systems made of poly(α-hydroxy acid) polymers has been hindered by the lack of information on the mechanical properties and biocompati...

The applications of zinc oxide (ZnO) nanowires (NWs) in implantable wireless devices, such as diagnostic nanobiosensors and nanobiogenerators, have recently attracted enormous attention due to their unique properties. However, for these implantable nanodevices, the biocompatibility and the ability to control the behaviour of cells in contact with ZnO NWs are demanded for the success of these im...

In the current chapter, digital morphometric analysis (DMA) was used to quantify two markers of biocompatibility around commonly used biomaterials. In the field of biomaterial evaluation for biocompatibility, more sophisticated methods are now being used to precisely characterize the elicited response from the surrounding tissue towards the implanted material. One reason for this is due to the ...