نتایج جستجو برای: bioconjugation
تعداد نتایج: 645 فیلتر نتایج به سال:
Understanding biological processes at the molecular level with accurate quantitation needs advanced bioanalysis. In this review, we describe dyedoped silica nanoparticles (NPs), their synthesis, bioconjugation, and applications in different bioanalysis formats. Silica-based nanomaterials have been developed with optical-encoding capabilities for the selective tagging of a wide range of biomedic...
One of the open challenges in chemical biology is to identify reactions that proceed with large rate constants at neutral pH values. As shown here, dialdehydes react with O-alkylhydroxylamines at rates of 500 M(-1) s(-1) at neutral pH values in the absence of catalysts. The key to these conjugations is an unusually stable cyclic intermediate, which ultimately undergoes dehydration to yield an o...
Introducing new physicochemical properties into proteins through genetically encoded Uaa (unnatural amino acid) incorporation can lead to the generation of proteins with novel properties not normally accessible with the 20 natural amino acids. Phenyl azide chemistry represents one such useful addition to the protein repertoire. Classically used in biochemistry as a non-specific photochemical pr...
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