S ingle-use bioprocessing equipment has come to thoroughly dominate precommercial biopharmaceutical production in only a decade. Yet even with this breakthrough, performance and cost pressures on biopharmaceutical facilities continue to grow. Demands for greater productivity, more efficiency, and lower costs are resulting in an unrelenting push for upstream improvements. Some people in the indu...

Continuous fermentations were carried out with a recombinant flocculent Saccharomyces cerevisiae strain in an airlift bioreactor. Once operating under steady state at a dilution rate of 0.45 h(-1), the bioreactor was contaminated with Escherichia coli cells. The faster growing E. coli strain was washed out of the bioreactor and the recombinant, slower growing flocculating S. cerevisiae strain r...

the performance of a forced-liquid vertical tubular loop bioreactor (vtlb), a forced-liquid horizontal tubular loop bioreactor (htlb) and a gas-induced external airlift loop bioreactor (ealb) were compared for production of biomass from natural gas. hydrodynamic characteristics and mass transfer coefficients were determined as functions of design parameters, physical properties of gases as well...