olanzapine is the frequently prescribed drug in children and adolescents with bipolar disorder, but unfortunately it has metabolic side-effects. on the other hand, in a number of melatonin studies on sleep cycle, regulation of metabolic abnormalities has been reported. therefore, we aimed to study effects of melatonin in reducing metabolic side-effects of olanzapine in 11-17 year-old patients w...

54-year-old male patient was admitted in endocrine ward and referred to our hospital for psychiatric consult due to malaise symptoms , dysphoric mood, irritability, insomnia, loss of appetite, increasing the amount of speech, lack of enjoyment of life, hopelessness, thoughts of worthlessness ,thoughts of death (these symptoms was started from 4 months ago ,after some career change ). other symp...

objective: the methylenetetrahydrofolate reductase (mthfr) gene polymorphism c677t is suspected to be a risk factor for psychiatric disorders, but it remains inconclusive whether the mthfr polymorphism c677t is imputed to vulnerability to schizophrenia and bipolar disorder. method: we prompted impetus to appraise this polymorphism in an iranian population. therefore, 90 patients with bipolar di...

OBJECTIVE Self-mutilation has traditionally been associated with borderline personality disorder, and seldom examined separately from suicide attempts. Clinical experience suggests that self-mutilation is common in bipolar disorder. METHODS A family study was conducted on the molecular genetics of depression and personality, in which the proband had been treated for depression. All probands a...

Several studies have proven the effectiveness of psychoeducation in bipolar II disorder patients; however, simpler psychoeducation is needed in daily medical practice. Therefore, we devised a simple individual psychoeducation program, which involved 20-minute sessions spent reading a textbook aloud in the waiting time before examination. Here, we report a successful case of simple individual ps...

Recent theories regarding the pathophysiology of bipolar disorder suggest contributions of both neurodevelopmental and neurodegenerative processes. While structural neuroimaging studies indicate disease-associated neuroanatomical alterations, the behavioural correlates of these alterations have not been well characterized. Here, we investigated multi-generational families genetically enriched f...

BACKGROUND The aim of the study was to investigate the total dyadic adjustment (including satisfaction, cohesion, consensus and affectional expression) among spouses of bipolar patients with I and II subtypes. SUBJECTS AND METHODS 82 subjects (46 women/ 36men) were enrolled in the study - 50 spouses of bipolar I (BD I) patients and 32 spouses of bipolar II (BD II) patients. We used an intervi...

Introduction Bipolar affective disorder type II is often misunderstood, neglected and rarely receives the attention it deserves remains undiagnosed. Despite its neglect insufficient diagnosis, an important diagnostic entity because causes significant suffering functional impairment, a chronic course of disease high suicide rate. Cognitive impairments multiple comorbidities that significantly af...