Abstract Production and consumption of poly(bisphenol‐A carbonate) resins are seeing a worldwide increase. However, their usage lifetimes short final disposition as landfills pose environmental health risks, due to the release toxic bisphenol‐A (BPA). The development alternative recycling routes is thus becoming subject increasing interest. In this review, main processes described critically co...

On the 25th July, the European Food Safety Authority (EFSA) launched an open consultation on a draft assessment of consumer exposure to BPA performed by the EFSA’s Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel). This was the Authority’s first review of exposure to BPA since 2006 and the first to cover both dietary and non-dietary sources. Data from scienti...

Bisphenol A (BPA) was used in the plastic industry and widely distributed in the environment, which might cause adverse effects to living organisms. In order to study the effects of BPA on the organs of mice brain, liver and testical, the KM mice were administrated to different concentrations of BPA (0, 0.09, 0.9, 9 mg/kg·d). After 14 days, the reactive oxygen species (ROS), malondialdehyde (MD...

BACKGROUND Bisphenol A (BPA) is a base chemical used extensively in many consumer products. BPA and its analogues are present in environmental and human samples. Many endocrine-disrupting chemicals, including BPA, have been shown to activate the pregnane X receptor (PXR), a nuclear receptor that functions as a master regulator of xenobiotic metabolism. However, the detailed mechanism by which t...

Bisphenol A is a widespread industrial chemical which over the past decade has demonstrated its toxicity as an endocrine disruptor. Chlorine present in drinking water may react with bisphenol A to form chlorinated derivatives, which have demonstrated a heightened level of estrogenic activity. In this work, we have comprehensively validated a method using on-line SPE-UPLC-MS/MS and isotope dilut...

BACKGROUND Endocrine-disrupting chemicals (EDCs) are widely found in the environment. Estrogen-like activity is attributed to EDCs, such as bisphenol A (BPA), bisphenol AF (BPAF), and zearalenone (Zea), but mechanisms of action and diversity of effects are poorly understood. OBJECTIVES We used in vitro models to evaluate the mechanistic actions of BPA, BPAF, and Zea on estrogen receptor (ER) ...

The potential developmental toxicity of environmental estrogenic endocrine disruptors have become a great concern in recent years. In this study, two typical environmental oestrogen, namely, bisphenol A (BPA) and genistein (GEN) were investigated for potential embryotoxicity using the embryonic stem cell test model. Afterwards, a 4×4 full factorial design and the estimated marginal means plot w...

This study evaluates the adsorption of bisphenol-A (BPA) from aqueous solutions using nanosilicaobtained from rice husk. Nanosilica (79 nm) was extracted from acid and thermal treated rice huskwaste. The rice husk nanosilica (RHS) was fully characterized through X-Ray DiffractionSpectroscopy (XRD), Scanning Electron Microscopy (SEM), X-Ray Fluorescence Spectroscopy(XRF) and Fourier Transmittanc...

A previously developed physiologically based pharmacokinetic (PBPK) model for bisphenol A (BPA) in adult rhesus monkeys was modified to characterize the pharmacokinetics of BPA and its phase II conjugates in adult humans following oral ingestion. Coupled with in vitro studies on BPA metabolism in the liver and the small intestine, the PBPK model was parameterized using oral pharmacokinetic data...