Fas (CD95, APO-1, TNFRSF6) is a TNF receptor superfamily member that directly triggers apoptosis and contributes to the maintenance of lymphocyte homeostasis and prevention of autoimmunity. Although FADD and caspase-8 have been identified as key intracellular mediators of Fas signaling, it is not clear how recruitment of these proteins to the Fas death domain leads to activation of caspase-8 in...

We present a new scenario of the emissive origin in the Steep Power Law (SPL) state of X-ray Binaries. The power-law component of X-ray emission is the synchrotron radiation of relativistic electrons in highly magnetized compact spots orbiting near the inner stable circular orbit (ISCO) of black hole and has a hard spectrum that extends to above MeV bands determined by electron acceleration rat...

We combine calibrated IUE data archive and new low resolution optical data for the T Tauri star LkH 264 covering the region from 1200 to 7000 A. The UV continuum is well tted by the combination of a black body at 4300 K plus hydrogenic free-free and free-bound emission from a dense plasma at 3.5 10 4 K plus the emission by a second black body. This last component is at T 8700 K and covers about...

Pseudoceros astrorum n. sp. is characterized by a smooth dorsal surface with a brown ground colour, and with net-like pattern of small black granules, white spots of different sizes uniformly distributed, a thin black sub-marginal band, and a white marginal rim. The pseudotentacles are dark brown with white tips and the anterior margin and cerebral region is devoid of pigmentation. The male sys...

HIV/AIDS trends in the United States depict a concentrated epidemic with hot spots that vary by location, poverty, race/ethnicity, and transmission mode. HIV/AIDS is a leading cause of death among US women of color; two-thirds of new infections among women occur in black women, despite the fact that black women account for just 14% of the US female population. The gravity of the HIV epidemic am...

Aspidoras mephisto n. sp. is described from the Anésio-Russão cave system, upper Tocantins River basin, Goiás, Brazil. The species can be readily distinguished from its congeners by troglomorphic features and also by presenting the following combination of features: infraorbital 1 generally with well-developed ventral laminar; or moderately developed; poorly-developed serrations on posterior ma...

Fishes currently assigned to Oreichthys cosuatis from the Western Ghats are shown to belong to a closely-related group of three valid species: Puntius coorgensis, which is raised from synonymy, and two new species, O. duospilus and O. incognito. Oreichthys coorgensis can be distinguished from its congeners by a combination of characters that include 22-23+1-2 scales in the longitudinal series w...

While describing the fishes of Ganges, Hamilton described Cyprinus ticto (now allocated to Pethia) from south-eastern parts of Bengal. The unavailability of type material and insufficient diagnostic characters in the original description resulted in ambiguities in the identity of this species. In this paper, we clarify the identity of P. ticto through an integrative-taxonomic approach. Pethia t...

Since 1996, the primary objective of the New Crop Pathology Program at the University of the Free State has been to conduct a systematic survey of diseases occurring in cactus-pear [Opuntia ficus-indica (L.) Miller] orchards throughout the country and to investigate possible relationships between disease-causing microorganisms and various insects, specifically Drosophila sp. Numerous fungal gen...

Driving simulators emerged as a promising technology for the analysis of driving conditions and road users’ behaviour in an attempt to tackle the problem of road accidents. The work presented herein demonstrates the design and development of a driving simulator that aims to contribute towards evaluating black spots in road networks by promoting rapid design of realistic models and facilitating ...