نتایج جستجو برای: blastomeres
تعداد نتایج: 1284 فیلتر نتایج به سال:
Transcription factor (TF) binding to DNA is fundamental for gene regulation. However, it remains unknown how the dynamics of TF-DNA interactions change during cell-fate determination in vivo. Here, we use photo-activatable FCS to quantify TF-DNA binding in single cells of developing mouse embryos. In blastocysts, the TFs Oct4 and Sox2, which control pluripotency, bind DNA more stably in pluripo...
Cell membrane regions characterized by alkaline phosphatase activity are described in cleaving mouse embryos and early blastocysts. Enzyme activity is demonstrated by light and electron microscopy, from the late 4-cell stage onwards, on the cell surfaces between blastomeres but not on the outer surface of the embryo. Experiments with dissociated morulae show that this is probably not an artifac...
In the early embryo of Tetrodontophora bielanensis (up to the stage of 500 blastomeres) nuage granules occur in two different locations: (1) in areas where the invaginating cleavage furrows have pushed fragments of the oosome into the yolk mass, and (2) in the oosome proper. In the first areas the granules are few in number and certain cells that have enclosed them in their cytoplasm eventually...
In animal development, numerous cell-cell interactions are mediated by the GLP-1/LIN-12/NOTCH family of transmembrane receptors. These proteins function in a signaling pathway that appears to be conserved from nematodes to humans. We show here that the aph-2 gene is a new component of the GLP-1 signaling pathway in the early Caenorhabditis elegans embryo, and that proteins with sequence similar...
To accommodate the large cells following zygote formation, early blastomeres employ modified cell divisions. Karyomeres are one such modification, mitotic intermediates wherein individual chromatin masses are surrounded by nuclear envelope; the karyomeres then fuse to form a single mononucleus. We identified brambleberry, a maternal-effect zebrafish mutant that disrupts karyomere fusion, result...
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