Plasma membrane blebs are dynamic cytoskeleton-regulated cell protrusions that have been implicated in apoptosis, cytokinesis, and cell movement. Influencing Rho-guanosine triphosphatase activities and subsequent actomyosin dynamics appears to constitute a core component for bleb formation. In this paper, we discuss recent evidence in support of a central role of nonapoptotic membrane blebbing ...

Anti-vascular endothelial growth factor (anti-VEGF) therapy used as adjunctive to glaucoma filtration surgery may help filtering bleb survival because vascular endothelial growth factor has an important role in the angiogenesis of new vessels and in the fibrogenesis, which lead to scar formation and bleb failure. Bevacizumab is a non-selective monoclonal antibody against all isoforms of VEGF-A....

BACKGROUND We investigated the outcome of 23-gauge transconjunctival pars plana vitrectomy (23G PPV) for the treatment of vitreoretinal disorder in patients with prior trabeculectomy. METHODS We retrospectively reviewed medical records of 23G PPV in 11 eyes that had functioning filtering blebs after trabeculectomy. The main outcome measures were the visual acuity, intraocular pressure (IOP) a...

CD43 down-regulation during the apoptosis of PMN (polymorphonuclear cells) is not caused by proteolysis or internalization. Could it be released with bleb-derived membrane vesicles? Membrane blebbing was followed by microscopy on PMN 'synchronized' by an overnight incubation at 15 degrees C before their spontaneous apoptosis at 37 degrees C. Released vesicles were quantified by flow cytometry. ...

Maniloff, Jack (Yale University, New Haven, Conn.), Harold J. Morowitz, and Russell J. Barrnett. Ultrastructure and ribosomes of Mycoplasma gallisepticum. J. Bacteriol. 90:193-204. 1965.-The ultrastructure of Mycoplasma gallisepticum strain A5969 has been studied by electron microscopy (thin-section and negative staining), ultracentrifugation, and chemical analysis. The list of ultrastructure i...

UNLABELLED Using finite element analysis, we evaluated if the site of an aortic bleb, known to be prone to rupture, coincides with the location of peak wall stress (PWS) in a patient-specific abdominal aortic aneurysm (AAA) model. REPORT PWS was not located at the bleb site, even when stress values were estimated for different bleb wall thicknesses (0.5-2.0 mm) while the rest of the AAA wall ...

PURPOSE Based on our previous report that showed enhanced transfer of mitomycin C to the sclera and the conjunctiva by dissolving the agent into a reversible thermo-setting gel, we conducted a study to investigate the efficacy of mitomycin C gel in the rabbit. METHODS We subconjunctivally injected 0.1 mL of the mitomycin C gel solution containing several different amounts of the agent. Trephi...

a case with bilateral spontaneous pneumothorax was presented. etiology, mechanism, and treatment were discussed on the review of literature. spontaneous pneumothorax is a clinical entity resulting from a sudden non traumatic rupture of the lung. biach reported in 1880 that 78% of 916 patients with spontaneous pneumothorax had tuberculosis. kjergaard emphasized 1932 the primary importance of sub...

AIM: To evaluate the safety and efficacy of posterior scleral application (a modified technique) an antimetabolite mitomycin C-soaked sponge in trabeculectomy for patients with glaucoma. METHODS: This retrospective study included 101 (115 eyes) glaucoma (aged 12–83y) who underwent using a placement method. A piece 3.5×10 mm2 was placed vertically posteriorly long side perpendicular to limbus. T...

Aim: To evaluate the influence of clear cornea phacoemulsification on filtering bleb morphology, function, and intraocular pressure (IOP) in glaucomatous eyes with previously successful filtering surgery. Methods: The clinical course of 30 patients (30 eyes) who underwent clear cornea phacoemulsification after successful filtering glaucoma surgery was prospectively evaluated. Mean IOP and filte...