This study examines the kinetics of the longest lasting form of short-term depression at excitatory hippocampal synapses. After initial depletion of the readily releasable pool (RRP), continued 20-Hz stimulation was found to be fast enough to maximally drive presynaptic neurotransmitter exocytosis; maximal is defined here as the rate needed to maintain the RRP in a nearly empty steady state. In...

Molecular weights of all hemocyanin aggregates which can be homogeneously isolated have been measured by sedimentation equilibrium. The larger aggregates, which are the ones present under physiological conditions, are, to a very close approximation, integral multiples of a 4.4 x 10(6)-dalton, 60 S species. Dissociation of the 60 S species at high pH gives heterogeneous samples in which the smal...

Inspired by the social psychology literature, we study the implications of categorical thinking on decision making in the context of a large normal form game. Every agent has a categorization (partition) of her opponents and can only observe the average behavior in each category. A strategy profile is a Conjectural Categorical Equilibrium (CCE) with respect to a given categorization profile if ...

A simultaneous flow-injection analysis (FIA) manifold that could analyse three ions from a single injection was designed, constructed, calibrated and used successfully to analyse Li(+), Na(+) and K(+). This FIA method was 10 times faster than the batch technique. The sample volume required was a fraction of about 1/110 to 1/75 that of the batch technique. The outputs were quite reproducible and...

The enlargement of the general-equilibrium structure to allow for default subject to appropriate credit limits and default penalties results in a construction of a simple mechanism for a credit using society. We show that there generically exists a price-normalizing bundle that determines a credit money along with appropriate credit limits and default penalties for the credit mechanism to selec...

Much forensic inference based upon DNA evidence is made assuming Hardy-Weinberg Equilibrium (HWE) for the genetic loci being used. Several statistical tests to detect and measure deviation from HWE have been devised, and their limitations become more obvious when testing for deviation within multiallelic DNA loci. The most popular methods-Chi-square and Likelihood-ratio tests-are based on asymp...

Many recent studies have reported the presence of two types of El Niño events in observation: Cold Tongue (CT) El Niño and Warm Pool (WP) El Niño. We investigate the sensitivity of a model simulating two types of El Niño by changing a convective triggering parameter (Tokioka parameter). When deep convections are highly suppressed with a large Tokioka parameter, the model is capable of simulatin...

This paper studies a solution concept for large stochastic games. A standard solution concept for a stochastic game is Markov perfect equilibrium (MPE). In MPE, each player’s optimal action depends on his own state and the state of the other players. By contrast, oblivious equilibrium (OE) is an approximation introduced in [5] where each player makes decisions based on his own state and the “av...

Paired-pulse depression (PPD) is a form of short-term plasticity that plays a central role in processing of synaptic activity and is manifest as a decrease in the size of the response to the second of two closely timed stimuli. Despite mounting evidence to the contrary, PPD is still commonly thought to reflect depletion of the pool of synaptic vesicles available for release in response to the s...

Although prospective logistic regression is the standard method of analysis for case-control data, it has been recently noted that in genetic epidemiologic studies one can use the "retrospective" likelihood to gain major power by incorporating various population genetics model assumptions such as Hardy-Weinberg-Equilibrium (HWE), gene-gene and gene-environment independence. In this article, we ...