We studied the effect of section of both carotid sinus nerves on arterial blood pressure in nine unanesthetized dogs. Four to seven recording sessions were conducted on each dog before and after sinus nerve section (SNS). During each session, histograms of mean arterial pressure during each heart cycle and of heart rate were assembled over 75 minutes. Then, responses to rapid aortic injection o...

Spinophilin controls intensity/duration of G protein-coupled receptor signaling and thereby influences synaptic activity. We hypothesize that spinophilin affects blood pressure through central mechanisms. We measured blood pressure and heart rate in SPL-deficient (SPL(-/-)), heterozygous SPL-deficient (SPL(+/-)), and wild-type (SPL(+/+)) mice by telemetry combined with fast Fourier transformati...

Given the hypothesis that air pollution is associated with elevated blood pressure and heart rate, the effect of daily concentrations of air pollution on blood pressure and heart rate was assessed in 131 adults with coronary heart disease in Helsinki, Finland; Erfurt, Germany; and Amsterdam, the Netherlands. Blood pressure was measured by a digital monitor, and heart rate was calculated as beat...

ranolazine is a new antianginal drug that is postulated to act through blocking of cardiac late sodium channels and improvement in cardiac blood flow. the present study has been carried out to investigate its possible effect on microcirculation of normal and diabetic rats’ cardiac muscle. methods: normal and diabetic rats were anesthetized. the chest was opened and a surface laser doppler flowm...

Measurements were made of heart rate, aortic blood pressure, systolic ejection period/beat, myocardial blood flow, and myocardial oxygen consumption in nine normal young men during three bouts of upright bicycle exercise: 1) at the workload which produced a heart rate of 120 beats/minute, 2) at the higher workload necessary to produce a heart rate of 120 beats/minute after administration of int...

Patients with hypertension have a blunted sensitivity of baroreflex control of heart period. In these patients, baroreflex sensitivity is positively related to heart rate variability and inversely related to blood pressure variability. We hypothesized that this relationship would also be evident in healthy normotensive subjects and that individuals with higher baroreflex sensitivity would have ...

Systemic intraarterial blood pressure and heart rate have been measured during exercise on a foot ergometer in 13 patients suffering from unilateral intermittent claudication. Each limb was exercised separately for 5 min. Both systolic and diastolic blood pressure increased to significantly higher levels during exercise with the diseased limbs than during exercise with the nondiseased limbs. No...