Objective(s):  There is a rising use of gold nanoparticles (AuNPs) in goods and in the medical fields but there is concern about the toxicity of them. So in this study spherical AuNPs with 3 different concentrations were applied for investigating their effects in vivo.   Materials and Methods:  40 male albino mice were randomly divided into sham, control, 25 ppm, 50 ppm, 100 ppm groups and were...

Introduction: Lidocaine is a class of Ib antiarrhythmic agent which available in various intravenous (IV) and topical forms. Systemic toxicity lidocaine has been reported following its IV injection or local infiltration for anesthesia, mostly. However, the application gel oral spray also possible. Manifestations induced systemic include neurologic cardiac symptoms. Reported cases after ingestio...

By LEIF G. SUHRLAND AND AUSTIN S. WEISBERGER T HE UNCOMMON OCCURRENCE of aplastic anemia following the therapeutic administration of chloramphenicol is well documented.’ However, erythropoietic depression associated with changes in iron metabolism, reticulocytopenia and vacuolization of erythroblasts is more frequent.2’3 If chloramphenicol is continued after these changes appear, leukopenia and...

As the backbone of highly active antiretroviral therapy (HAART), nucleoside reverse transcriptase inhibitors (NRTIs) have effectively improved outcomes for HIV-infected patients. However, long-term treatment with NRTIs can cause a series of pathologies associated with mitochondrial toxicity. To date, the status and mechanism of mitochondrial toxicity induced by NRTIs are still not clear, especi...

The role of chelating agents for the prevention, intervention, and treatment of exposures to toxic metals was the topic of a conference held at the National Institute of Environmental Health Sciences, 22-23 September 1994. The objective of the conference was to review experimental and clinical studies concerned with the effectiveness and potential toxicity of chelating agents used to reduce the...

The effects of co-administration of a cassava rich diet and alcohol in rats were investigated. The animals were divided into four groups (1) Control, (2) Alcohol, (3) Cassava and (4) Alcohol + Cassava. Consumption of alcohol along with cassava reduced the alcohol induced toxicity which was evidenced by the lower activities of GOT, GPT, GGT, acid phosphatase and alkaline phosphatase in the liver...

Chimeric antigen receptor (CAR)-modified immune cell therapy has become an emerging treatment for cancers and infectious diseases. NK-based immunotherapy, particularly CAR-NK cell, is one of the most promising 'off-the-shelf' development without severe life-threatening toxicity. However, bottleneck developing a successful achieving sufficient numbers non-exhaustive, long-lived, cells from third...

The use of ozone therapy is reported to be effective in a variety of viral illnesses, including HIV disease. We performed a phase I study of ozone blood treatments in 10 patients in whom no significant toxicity was observed. Three patients with moderate immunodeficiency showed improvement in surrogate markers of HIV-associated immune disease. A phase II controlled and randomized double-blinded ...

Diabetes is a disease in which premature development of conditions which increase blood coagulation are the leading cause of death. A reduction in the consequences of elevated glucose levels is the main focus of clinical treatment. It has been determined that the addition of glucose to anti-coagulated human blood, followed by incubation for 24 hours results in the generation of a hypercoagulabl...