PURPOSE Aromatase inhibitors (AIs) have been recently associated with hip fractures. We present a case series of breast cancer survivors and a systematic review of bone health care in breast cancer. EXPERIMENTAL DESIGN We completed clinical assessments and bone density testing (BMD) of hip fractures from January 2005 to December 2008. Prefracture and 12-month functional status was obtained. S...

The biotyping scheme of Baird-Parker was applied to cultures of Staphylococcus epidermidis from patients. In all, 63.6% of 228 cultures belonged to biotype 1, followed by biotypes 4, 3, and 2 in decreasing order of incidence. When classified according to clinical source of isolation, cultures of S. epidermidis were most frequently isolated from urine, with 39.5% of 228 cultures from this source...

MARY A retrospective study of 228 consecutive carotid endctomies was conducted to determine the operative stroke and lity rate in two 600-bed community hospitals. The combined -mortality rate for the series was 21.1% (48 of 228). Eleven :erectomies were performed for asymptomatic bruits and the ned stroke-mortality rate was 18.2% (2 of 11). Fifty-seven endctomies were performed for transient is...

We investigate the proposal that integrins and focal adhesion kinase (FAK) form a complex that has structural and signaling functions in eggs. FAK protein is present in eggs and is phosphorylated at fertilization. pY(397)FAK localizes to the membrane 30 min after fertilization, which correlates with the expression of βC integrins and egg cortex development. The βC integrin and pY(397)FAK coimmu...

Aims: To evaluate the utility of endoscopic obliterative therapy with n-butyl-2-cyanoacrylate (tissue adhesives) for gastrointestinal varices and to investigate the incidence of serious complications. Methods: Endoscopic obliterative therapy with n-butyl-2-cyanoacrylate was performed on 228 gastrointestinal variceal patients; 221 gastric varices, 5 duodenal varices, and 2 anastomotic varices af...

The amino acid sequence requirements in the hinge of human immunoglobulin A1 (IgA1) for cleavage by IgA1 proteases of different species of Streptococcus were investigated. Recombinant IgA1 antibodies were generated with point mutations at proline 227 and threonine 228, the residues lying on either side of the peptide bond at which all streptococcal IgA1 proteases cleave wild-type human IgA1. Th...

Pulmonary artery smooth muscle cells (PASMC), in pulmonary arterial hypertension (PAH), contribute to obliterative vascular remodelling and are characterised by enhanced proliferation, suppressed apoptosis and, a much less studied, increased migration potential. One of the major proteins that regulate cell migration is focal adhesion kinase (FAK), but its role in PAH is not fully understood. We...

Biomarkers are essential for assessment of oxidative stress and evaluation of antioxidant capacity in vivo. Total hydroxyoctadecadienoic acid (HODE)and7-hydroxycholesterol measured afterreduction and saponification ofbiological fluidsmaybeusedasreliablebiomarker. J. Med. Invest. 52 Suppl. : 228-230, November, 2005