Group B Streptococcus (GBS) is the major cause of human neonatal infections. A single clone, designated CC17-GBS, accounts for more than 80% meningitis cases, most severe form infection. However, events allowing blood-borne GBS to penetrate brain remain largely elusive. In this study, we identified host transmembrane receptors ?5?1 and ?v?3 integrins as ligands Srr2, a CC17-GBS–specific adhesin...

objective due to the high prevalence of syndrome of inappropriate antidiuretic hormone secretion (siadh). this study was carried out to evaluate the prevalence and relevant parameters of siadh in children with septic and aseptic memingitis hospitalized at kashan shahid beheshti hospital between 1996 and 2006. materials & methods this descriptive study was conducted on 230 patients with meningit...

Bacterial meningitis is the most common and serious bacterial infection of the central nervous system (CNS), characterized by an acute purulent infection of the piamater, arachnoid and subarachnoid space1. Approximately 1.2 million cases are estimated to occur annually world-wide, resulting in 135,000 deaths2,3. Streptococcus pneumoniae and Neisseria meningitidis are the main etiologic agents r...

OBJECTIVE To review the ages of patients with recurrent herpes simplex virus type 2 (HSV-2) meningitis. DESIGN Case report and literature review back to 1970. SETTING Referral Veterans Affairs hospital. RESULTS Our patient developed his first episode of recurrent HSV-2 meningitis at 78 years of age, 57 years after his only episode of genital herpes simplex infection. Of 223 patients in th...

We reviewed the records of 70 consecutive adult patients with meningitis after a neurosurgical procedure, to determine the characteristics that might help to distinguish a sterile postoperative chemical meningitis from bacterial infection. The spinal fluid profiles in bacterial and chemical meningitis are similar. The exceptions are that a spinal fluid white blood cell count > 7500/microL (7500...

Meningitis is an uncommon complication of neurosurgical procedures, with an incidence of 1.1% to 2.5%. Although unusual, the frequency of nosocomial Gram-negative meningitis appears to be increasing. Gram-negative meningitis has been documented following disruption of the dura-arachnoid barrier secondary to trauma or surgery. The association of Gram-negative bacillary meningitis with neurosurgi...

AIMS To determine the level of serum procalcitonin and cerebrospinal fluid cytokines in children with bacterial or viral meningitis and to document the use of these parameters in differential diagnosis. RESULTS Before the start of antibiotic treatment, serum procalcitonin and tumor necrosis factor alpha levels were found to be higher in acute bacterial meningitis compared with viral meningiti...

BACKGROUND In Niger, epidemic meningococcal meningitis is primarily caused by Neisseria meningitidis (Nm) serogroup A. However, since 2002, Nm serogroup W135 has been considered to be a major threat that has not yet been realized, and an unprecedented incidence of Nm serogroup X (NmX) meningitis was observed in 2006. METHODS Meningitis surveillance in Niger is performed on the basis of report...

background and objective: bacterial meningitis is an important cause of mortality and long-term neural morbidity. immediate diagnosis and treatment are necessary in appropriate time. this study was designed in afzalipour hospital in kerman to evaluate meningitis causes, frequency and csf laboratory changes. patients and methods: in this retrograde descriptive study from september 2003 to septem...

Herpes simplex virus type 1 and 2 can infect the human nervous system causing meningitis and encephalitis. HSV meningitis tends to be benign, but HSF encephalitis can have a high morbidity and mortality despite treatment. We present a case of HSV meningitis leading to hydrocephalus without evidence of encephalitis. The patient had persistent hydrocephalus requiring long term CSF diversion despi...