The repair of bone defects is of particular interest for orthopedic, oral, maxillofacial, and dental surgery. Bone loss requiring reconstruction is conventionally addressed through bone grafting. Depending on the size and the location of the defect, this method has limits and risks. Biomaterials can offer an alternative and have features supporting bone repair. Here, we propose to evaluate the ...

Poly-L-lactic acid (PLLA) nanofibrous membranes are widely utilized for tissue regeneration. Low intensity pulsed ultrasound (LIPUS) has been considered as a feasible modality for bone union. The aim of the present study was to investigate the potential synergistic effect of LIPUS and PLLA electrospun nanofibrous membranes on large cortical bone defects in rabbits in vivo. The bilateral rabbit ...

Background: In several conditions we have face cranial bone defects. Reconstruction of these defects remains one of the most challenging problems encountered by craniofacial surgeons. Objective: To evaluate bone repair in cranial bone defects by use of an implant made of octacalcium phosphate in combination with bone matrix gelatin (OCP/BMG). Methods: We used 40, 5–6-week-old male Sprague-Dawle...

Acetabular revision is a challenging operation, especially when dealing with major bone loss and poor bone quality. This article describes a detailed approach to defect analysis, including measurement of bone deficiency and bone quality. A custom-made titanium implant, with precisely outlined flanges to the host bones of the ilium, ischium, and pubis, taking into account the bone quality for op...

Background: Nitric oxide (NO) has several functions in bone healing and affects metabolism. Selective inducible NO synthase (iNOS) inhibitors can be used to assess the efficacy of for defects. This study sought local effect different concentrations aminoguanidine hydrochloride (AG), a selective iNOS inhibitor, on rats. Materials Methods: In this animal experimental study, 72 rats were divided i...

Background: Bone defect healing is a multidimensional procedure with an overlapping timeline that involves the regeneration of bone tissue. Due to bone's ability regenerate, vast majority abnormalities can be restored intuitively under right physiological conditions. The goal this study examine immunohistochemistry sialoprotein in order determine effect local application on rat tibia generated ...

New strategies to fulfill craniofacial bone defects have gained attention in recent years due to the morbidity of autologous bone graft harvesting. We aimed to evaluate the in vivo efficacy of bone tissue engineering strategy using mesenchymal stem cells associated with two matrices (bovine bone mineral and α-tricalcium phosphate), compared to an autologous bone transfer. A total of 28 adult, m...

Secondary alveolar bone grafting is a method that enables an excellent oral rehabilitation of the patients having cleft palate. Many types of bone grafts have been used for reconstruction of the cleft, including autogenous bone and bone substitutes. Platelet-rich fibrin (PRF) has been shown to be effective in grafting the defect. The aim of this presentation is to report the closure of an alveo...

OBJECTIVE To explore the application value of injectable bioactive glass in the restoration of the oral bone defect. PATIENTS AND METHODS This study included 58 consecutive patients with oral bone defect > 1 mm, these patients were randomly assigned to a control group (n=26, Hydroxyapatite bioceramics) and an observation group (n=32, Injectable bioactive glass). The purpose of this study was ...