The skeleton plays a crucial role in human health. Comprehensive and non‐invasive visualization of the bone is high demand to detect bone‐related diseases. Clinically, traditional imaging methods still suffer from poor sensitivity, long capture time, inevitable ionizing radiation are inadequate for providing real‐time spatial information regarding cellular activity. Recently, various new techni...

Hemophagocytic syndrome is a non-malignant process that is characterized clinically by fever, hepatomegaly, splenomegaly, pancytopenia in peripheral blood, and reactive histiocytes in the bone marrow. Bacterial infectious diseases like typhoid fever and brucellosis and viral infections including CMV, herpes viruses, and Epstein-Barr virus are diagnosed as the cause of this syndrome. In thi...

INTRODUCTION Chronic inflammatory diseases, such as rheumatoid arthritis and periodontitis, cause the bone destruction by promotion of the differentiation of monocyte/macrophage lineage cells into mature osteoclasts (OCs) with active bone-resorbing character. However, the detailed mechanisms underlying this disorder remain unclear. We herein investigated the role of urokinase plasminogen activa...

INTRODUCTION Sphingolipids belong to a complex class of lipid molecules that are crucially involved in the regulation of important biological processes including proliferation, migration and apoptosis. Given the significant progress made in understanding the sphingolipid pathobiology of several diseases, sphingolipid-related checkpoints emerge as attractive targets. Recent data indicate the mul...

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 introduction : alveolar bone level is changed due to the balance between bone formation and resorption. radiographic examination has an important role in the diagnosis and treatment of periodontal diseases. this study was performed to compare the accuracy of vertical bitewing and periapical radiography in anterior mandibular ...

Although conditions leading to bicytopenia and pancytopenia secondary to infiltrative diseases of the bone marrow are seen, a profound anemia or hemorrhages are frequently observed in such cases. As bone marrow infiltrations may be associated with primary hematological diseases such as leukemia, lymphoma or myeloma, rarely they may also be associated with solid tumor metastases. Here we have pr...

The World Health Organisation has declared the period 2000 to 2010 the Bone and Joint Decade. This is indeed timely and appropriate. Hundreds of millions of people in the world today are beset with a host of disabilities caused by trauma, ageing and degeneration and other affections of the musculo-skeletal system. With the state of art of orthopaedic surgery and rheumatology, sufferers of bone ...

Diseases that affect the regulation of bone turnover can lead to skeletal fragility and increased fracture risk. Members of the TGF-beta superfamily have been shown to be involved in the regulation of bone mass. Activin A, a TGF-beta signaling ligand, is present at high levels in bone and may play a role in the regulation of bone metabolism. Here we demonstrate that pharmacological blockade of ...

Materials and methods The reconstructed site was the humerus in 15 cases, the radius, the ulna or the wrist joint in 22 cases, carpal or metacarpal bone in 52. The etiologies consisted of three traumatic bone defects, 13 traumatic nonunions of long bone, two osteonecroses of the humeral head, eight osteomyelitis, nine case after resections of bone tumor, two congenital pseudoarthroses of the ul...