background: bone marrow and umbilical cord stromal cells are multipotential stem cells that have the ability to produce growth factors that play an important role in survival and generation of axons. the goal of this study was to evaluate the effects of the two different mesenchymal stem cells on peripheral nerve regeneration. materials and methods: in this experimental study, a 10 mm segment o...

This literature review presents the most recent developments in the management of multiple myeloma, which is characterized by the presence of abnormal plasma cells (myeloma cells) that accumulate into the bone marrow. Aspects related to pathophysiology, clinical manifestations, laboratory, study and treatment are described. These pieces of information  are necessary to accomplish a better ...

objective: tendon never returns to its complete biological and mechanical properties after repair. bone marrow and, recently, adipose tissue have been used as sources of mesenchymal stem cells which have been proven to enhance tendon healing. in the present study, we compared the effects of allotransplantation of bone marrow derived mesenchymal stromal cells (bmscs) and adipose derived stromal ...

background: despite major progress in our general knowledge related to the application of adult stem cells, finding alternative sources for bone marrow mesenchymal stem cells (mscs) has remained to be challenged. in this study successful isolation, multilineage differentiation, and proliferation potentials of sheep mscs derived from bone marrow, adipose tissue, and liver were widely investigate...

Human mesenchymal stem cells (hMSCs), which also called mesenchymal stromal cells, are multipotent stem cell. Human MSCs typically are positive for the surface markers CD44, CD73, CD90, CD105, CD106, and also negative for hematopoietic markers CD34 and CD45.These cells can be isolated from postnatal bone marrow, adipose tissue, placenta, and scalp tissue, as well as from various fetal tissues. ...

In a retroviral rat model, we have investigated the nontransforming effects of murine leukemia virus FB29 on the bone marrow. Upon intraperitoneal inoculation with murine leukemia virus FB29 of either neonatal or adult rats, bone marrow cells became massively infected within the first 12 days postinoculation. In neonatally inoculated rats, a persistent productive bone marrow infection was estab...

Adult bone marrow contains progenitor cells that can extricate themselves from their bone marrow cavity niche, and engraft within foreign tissues, whereupon they produce specific differentiated adult lineages. Bone marrow engraftment is upregulated with increasing regenerative pressure, which has triggered speculation as to the therapeutic potential of bone marrow cells. In this thesis, I descr...

In the bone marrow, endothelial cells are a major component of the hematopoietic stem cell vascular niche and are a first line of defense against inflammatory stress and infection. The primary response of an organism to infection involves the synthesis of immune-modulatory cytokines, including interferon alpha. In the bone marrow, interferon alpha induces rapid cell cycle entry of hematopoietic...

The majority of patients with small cell carcinoma of the lung (SCCL) have bone marrow involvement detected by monoclonal antibodies (mAb). High dose chemotherapy followed by autologous bone marrow transplantation may improve treatment results for patients with SCCL, but the bone marrow may need to be purged of contaminating tumor cells. This study investigates the reactivity of a panel of mAb ...

introduction: as an inherited neurodegenerative disease, huntington's disease is accompanied with wide neuronal degeneration in neostriatum and neocortex. progress of the disease causes disabling clinical effects on movements, recognition and physiology of the body, and finally results in death. at this stage of knowledge we are, there is no effective therapeutic strategy for diminishing t...