We report the case of a 35-year-old woman with chronic active Epstein-Barr virus (EBV) infection (CAEBV). She underwent allogeneic bone marrow transplantation (BMT) from an unrelated male donor and achieved a complete response. However, her CAEBV relapsed one year after BMT. EBV-infected cells proliferated clonally and revealed a 46XY karyotype. In addition, the infecting EBV strain differed fr...

Using monoclonal antibodies to cell surface antigens and fluorescent cell sorter analysis, we studied peripheral blood lymphocyte subsets after bone marrow transplantation (BMT). In 13 patients studied 3 mo or more after BMT, the ratio of T-cell subsets defined by antibodies OKT4 and OKT8 was reversed (OKT4/OK%8 = 0.7 +/- 0.3) in comparison to normal volunteers or bone marrow donors (ratio OKT4...

Case Report A previously well 10-year-old Vietnamese boy with exanthematous fever, jaundice (Alanine aminotransferase 688 U/L, Aspartate aminotransferase 340 U/L) and pancytopoenia (Haemoglobin 4.2 g/dL, WBC 1.7 x 109/L, and platelets < 20 x 109/L) developed grade 4 hepatic encephalopathy at 10 weeks of illness. Extensive workup failed to reveal the aetiology. At 11 weeks of illness, a liver tr...

Refractory anemia with ringed sideroblasts (RARS) is an extremely rare type of myelodysplastic syndrome in children. We describe a 10-year-old boy with RARS presented with pancytopenia. He remained relatively stable with only a few transfusions until age of 20 years, when he underwent an allogeneic bone marrow transplantation (BMT) because of increased transfusion requirements. He remains in co...

Idiopathic pneumonia syndrome (IPS) is a major complication of allogeneic bone marrow transplantation (BMT). We have shown that experimental IPS is associated with increased levels of LPS and TNF-alpha in the bronchoalveolar lavage (BAL) fluid. We hypothesized that the deleterious effects of these inflammatory mediators in the lung may be linked to gut injury that develops after BMT. To test th...

The bone marrow is an important source of Abs involved in long-term protection from recurrence of infections. Allogenic bone marrow transplantation (BMT) fails to restore this working memory. Attempts to overcome this immunodeficiency by immunization of the donor have not been very successful. More needs to be known about transfer of B cell memory by BMT. We tracked memory B cells from the dono...

Representatives of 17 bone marrow transplant (BMT) teams met to discuss the problems of infection after BMT. With experience of more than 2200 transplanted patients over the past 10 yr, the changes in the patterns of infection were surprisingly similar. Deaths due purely to bacterial infection have greatly diminished and the major early problems today result from fungi and cytomegalovirus. The ...

We studied 24 recipients of autologous bone marrow transplantation (ABMT) or allogeneic BMT (BMT) to determine whether impaired erythropoietin (Epo) response to anemia could delay full erythropoietic recovery. Observed Epo levels were compared with predicted levels based on the relationship between Epo and hematocrit in 125 control subjects. Circulating Epo levels were normal during conditionin...

MPS VI1 mice are deficient in P-glucuronidase and share many clinical, biochemical, and pathologic characteristics with human mucopolysaccharidosis type VI1 (MPS VII). We have shown that syngeneic bone marrow transplantation (BMT) prolongs survival and reduces lysosomal storage in many organs of the MPS VI1 mouse. In this report, we quantify the hearing loss and determine the impact of syngenei...

Evidenee that eonventional treatment (ehemotherapy and/or immunotherapy) produees a substantial number of eures in aeute myeloid leukaemia (AML) is laeking (PowIes et al. 1980a). Thomas et al. (1977) showed that there was a proportion of long-term survivors of a group of AML patients treated with high-dose eyc1ophosphamide, total body irradiation (TBI) and allogeneie bone marrow transplantation...