The 10boron neutron-capture therapy (BNCT) is an emerging antitumoral method that shows increasing biomedical interest. BNCT based on the selective accumulation of isotope within tumor, which then irradiated with low-energy thermal neutrons, generating nuclear fission produces 7lithium, 4helium, and γ rays. Simple catechol-borate esters have been rather overlooked as precursors melanin biosynth...

Boron neutron capture therapy (BNCT), a binary treatment modality that can potentially irradiate tumor tissue within cellular dimensions, is critically dependent on the preferential delivery of '"IS to individual neoplastic cells. In this study, ion microscopy was used to quantitatively evaluate the selectivity of p-boronophenylalanine-fructose (BPA-F) in the rat 9L gliosarcoma brain tumor mode...

Background and purpose: Accelerator-Based Boron Neutron Capture Therapy is a radiotherapy based on compact accelerator neutron sources requiring an epithermal field for tumour irradiations. Neutrons of 10 keV are considered as the maximum optimised energy to treat deep-seated tumours. We investigated, by means Monte Carlo simulations, range from eV in order optimise function depth. Methods: A S...

A number of boron neutron capture therapy (BNCT) clinical trials are currently underway around the world. Due to the small number of patients at each of the individual centers, it is desirable to pool the clinical data from each into one patient database. Before this can be done, a number of differences between the clinical centers must be evaluated. The patients treated at the BNCT centers at ...

The prognosis for patients with the high-grade cerebral glioma glioblastoma multiforme is poor. The median survival for primary tumors is < 12 months, with most recurring at the site of the original tumor, indicating that a more aggressive local therapy is required to eradicate the unresectable "nests" of tumor cells invading into adjacent brain. Two adjuvant therapies with the potential to des...

Large area patterned boron nanocones with low turn-on electric field of 2.8 V microm(-1) and low threshold electric field of 3.8 V microm(-1) were synthesized by a pre-manipulation to pattern the catalyst with a grid template as mask. The good field emission performance of patterned boron nanocones arise from the decreased screening effect and a favorable orientation of the nanocones. These res...

A project aimed at the development of an accelerator facility devoted to Boron Neutron Capture Therapy (BNCT) is ongoing at the National Atomic Energy Commission of Argentina [1]. In a first stage of development, the accelerator will be capable of delivering proton or deuteron beams of 30 mA at about 1.4 MeV which is suitable for neutron production through the 9Be(d,n) reaction. In this context...

Since 1998, we are performing clinical studies on treatment of GBM using conventional fractionated photon radiation therapy (CRT), proton beam therapy (PBT) or boron neutron capture therapy (BNCT). We investigated whether these radiation modalities improves the survival of patients with GBM. Sixty-eight cases of newly diagnosed GBM have been treated in our institution. After surgery, radiation ...