Purpose: Drugs that modify the production of cytokines may affect fracture healing. The immunosuppressive drug cyclosporin A is widely used to modify the immune response in transplantations and in treatment of rheumatoid disorders. We wanted to analyze the effect of cyclosporin A on fracture healing and on the development of trauma induced osteopenia. Methods: Experimental tibia fractures were ...

Background: The fracture of the mandible is the second most common facial bone injury.  When this injury occurs, it could be serious with complications that may even result in death. Objective: To evaluate the current trends in mandibular fracture (MF) in southern Iran. Methods: In a cross-sectional study, several parameters including age, sex, cause of fracture, anatomical site of fracture, pr...

OBJECTIVES To examine the association between body composition (fat mass, lean mass and body mass index, BMI) and bone health (bone mineral density, BMD and fracture risk) in urban black South African women. DESIGN A cross sectional study examining associations between body composition, dietary intake (food frequency questionnaire), habitual physical activity (Activity energy expenditure (AEE...

Mixing implants with differing metallic compositions has been avoided for fear of galvanic corrosion and subsequent failure of the implants and of bone healing. The purpose of this study was to evaluate upper-extremity fractures treated with open reduction and internal fixation with metallic implants that differed in metallic composition placed on the same bone. The authors studied the effects ...

Age-related deterioration of the fracture properties of bone, coupled with increased life expectancy, is responsible for increasing incidence of bone fracture in the elderly, and hence, an understanding of how its fracture properties degrade with age is essential. The present study describes ex vivo fracture experiments to quantitatively assess the effect of aging on the fracture toughness prop...

OBJECTIVE To investigate the risk of bone fracture sustained by obese children exposed to falls. The bone fracture risk of obese children would be greater than that of their nonobese counterparts was hypothesized. DESIGN AND METHODS Finite element-based computational models for children that reflected various levels of obesity by varying body mass and the thickness of the subcutaneous adipose...

Osteoporosis and type 2 diabetes mellitus (T2DM), both prevalent in aging and westernized societies, adversely affect the health of elderly people by causing fractures and vascular complications, respectively. Recent experimental and clinical studies show that the disorders are etiologically related through the actions of osteocalcin and adiponectin. Meta-analyses of multiple clinical studies s...

BACKGROUND Phytoestrogens are plant-derived natural molecules having some bone forming and bone substituting effects. In the present study, the role of phytoestrogens on bone healing was investigated in a rabbit fracture model. METHODS Twenty-two New Zealand white rabbits with right tibia fracture were divided into two groups randomly. The plant derived extract of Vitex agnus-castus L. (Verbe...

low-intensity laser therapy (lilt) is defined to supply direct biostimulative light energy to the cells. while several studies have demonstrated that lilt has stimulating effects on bone cells and can accelerate the repair process of the bone, others reported delayed fracture healing or no effects after lilt. the aim of this article was to review the studies evaluating the biomodulation effects...

Fracture risk is determined by bone mass, geometry, and microstructure, which result from peak bone mass (the amount attained at the end of pubertal growth) and from the amount of bone lost subsequently. Nutritional intakes are an important environmental factor that influence both bone mass accumulation during childhood and adolescence and bone loss that occurs in later life. Bone growth is inf...