Transcriptome-wide maps of RNA binding protein (RBP)-RNA interactions by immunoprecipitation (IP)-based methods such as RNA IP (RIP) and crosslinking and IP (CLIP) are key starting points for evaluating the molecular roles of the thousands of human RBPs. A significant bottleneck to the application of these methods in diverse cell lines, tissues, and developmental stages is the availability of v...

A shop floor control system (SFCS), the central part of a computer integrated manufacturing (CIM) system, is responsible for resolving various problems, such as planning and scheduling, task execution, recovery from errors due to the dynamic nature of the shop floor, etc. However, the high cost of SFCS development and maintenance has been recognized as a significant bottleneck in building autom...

Word Sense Disambiguation (WSD) is considered as one of the most difficult tasks in Natural Language Processing. Probabilistic methods have shown their efficiency in many NLP tasks, but they imply a training phase and very few resources are available for WSD. This paper aims at showing how to make the most of size-limited resources in order to partially overcome the knowledge acquisition bottle...

The storage of hydrogen is considered as the bottleneck in the implementation of portable fuel cell power generating systems. The necessary experimental studies to discover and develop appropriate storage materials are always time-limited. We discuss herein the approach of an uncomplicated and accessible computationally based analysis of database knowledge towards the identification of promisin...

Word Sense Disambiguation (WSD) systems require large sense-tagged corpora along with lexical databases to reach satisfactory results. The number of English language resources for developed WSD increased in the past years while most other languages are still under-resourced. The situation is no different for Dutch. In order to overcome this data bottleneck, the DutchSemCor project will deliver ...

In this report we comment upon subject selection and methodology, and we describe some recent studies of syntactic processing in aphasia. Our data show that, like neurologically intact subjects, Wernicke's patients reactivate moved constituents (instantiate coreference) at the site of their extraction (even for sentences that they do not understand). Broca's patients, by constrast, are shown no...

For the conversion of plant biomass into various bioproducts, a significant bottleneck is enzymatic hydrolysis of lignocelluloses to soluble sugars. These sugars are then metabolized through various natural or engineered pathways toward products of interest. The success of projected biorefinery processes depend to a large extent on the economics of hydrolytic enzyme production. Presently, mesop...

Replicated state machines use agreement protocols such as Paxos to order client requests. These protocols are not scalable and can quickly become a performance bottleneck as the degree of fault-tolerance and the demand for throughput performance increase. We propose a scalable agreement protocol that can utilize additional resources to provide higher throughput, while guaranteeing linearizabili...

The rapid evolution of Next Generation Sequencing technology will soon make it possible to test patients for genetic disorders at population scale. However, clinical interpretation of human variants extracted from raw NGS data in the clinical setting is likely to become a bottleneck, as long as it requires expert human judgement. While several attempts are under way to try and automate the diag...

Modern processors provide mechanisms (such as dutycycle modulation and cache prefetcher adjustment) to control the execution speed or resource usage efficiency of an application. Although these mechanisms were originally designed for other purposes, we argue in this paper that they can be an effective tool to support fair use of shared on-chip resources on multi-cores. Compared to existing appr...