The brain contains more than 100 billion neurons that communicate with each other via axons for the formation of complex neural networks. The structural mappingof suchnetworksduringhealthanddiseasestates is essential for understandingbrain function.However, our understanding of brain structural connectivity is surprisingly limited, due in part to the lack of noninvasivemethodologies tostudyaxon...

Axonal injury represents a critical target area for the prevention and treatment of traumatic brain and spinal cord injuries. Finite element (FE) models of the head and/or brain are often used to predict brain injury caused by external mechanical loadings, such as explosive waves and direct impact. The accuracy of these numerical models depends on correctly determining the material properties a...

Tranexamic acid (TXA) reduces blood loss by inhibiting the enzymatic breakdown of fibrin. It is often used in surgery to decrease bleeding and the need for blood transfusion. In 2011, results from a multi-center, randomized, and placebo-controlled trial (CRASH-2 trial) showed that TXA (1 g loading dose over 10 min followed by an infusion of 1 g over 8 h) safely reduces mortality in bleeding tra...

BACKGROUND Laparoscopic Nissen fundoplication is an effective technique for the symptomatic relief of the manifestations of gastroesophageal reflux disorder but is associated with a 0.8-1% rate of gastroesophageal perforation. Early detection and repair of these injuries is critical to patient outcome, but occult injuries occur and may be missed. Gastric insufflation technique evaluates the int...

This case report aims to extend analytical thinking and clinical reasoning of clinicians and radiographers when presented with diagnosing premature neonatal brain injuries (PNBI). The report considers the uses and merit of magnetic resonance imaging (MRI) in the primary assessment of PNBI. The traditional technique of cranial ultrasound as the first modality of choice can have several limitatio...

Traumatic brain injury (TBI) occurs when a sudden trauma causes damage to the brain. TBI can result head suddenly and violently impacts an object or pierces skull enters tissue. Secondary injuries after traumatic lead impairments on cerebral oxygenation autoregulation. Considering that secondary often take place within first hours trauma, noninvasive monitoring might be helpful in providing ear...

background: the global status report of the world health organization (who) on road safety suggested that india is leading in road traffi c accidents in the world. according to the report on road accidents in india in 2010 by the transport research wing, ministry of road transport and highways, new delhi, kerala ranked third in accidents per lakh population and second in persons injured per lak...

The medial collateral ligament (MCL) is commonly injured in the setting of anterior cruciate ligament (ACL) injuries. Because the MCL has better healing capacity than the ACL, the general perception is that MCL injuries can be treated conservatively. Treating these injuries conservatively, however, can lead to residual valgus laxity. Furthermore, it delays time to surgery, which prevents acute ...

Preliminary positive results of transcranial direct current stimulation (tDCS) in enhancing the effects of cognitive and motor training indicate that this technique might also be beneficial in traumatic brain injury or patients who had decompressive craniectomy for trauma and cerebrovascular disease. One perceived hurdle is the presence of skull defects or skull plates in these patients that wo...