background the relationship between biomarkers and imaging features is important because imaging findings can predict molecular features. objectives to investigate the relationship between clinicopathologic and radiologic factors and the immunohistochemical (ihc) profiles associated with breast cancer. patients and methods from december 2004 to september 2013, 200 patients (mean age, 56 years; ...

background & aim: family caregivers of cancer patients are at a high risk of physical, psychological and emotional problems, which could adversely affect their quality of life. this study aimed to evaluate the quality of life of the female caregivers of breast cancer patients in sabzevar, iran. methods: this cross-sectional study was conducted on 105 participants in sabzevar, iran in 2013. subj...

breast cancer is the leading cause of malignancy among women. screening using mammography is proposed as an effective intervention for reducing early deaths due to breast cancer. we conducted a systematic review to assess the cost-effectiveness of such screening programs. we searched medline, scopus and google scholar and complemented it by other searches using sensitive search terms from 1993-...

it has been reported that cxcl12 binding to cxcr4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on mcf-7 and mda-mb-23...

background: thioredoxin reductase 1 (txnrd1) and thioredoxin interacting protein (txnip) also known as thioredoxin binding protein 2 or vitamin d3-upregulated protein 1 are key players in oxidative stress control. thioredoxin (trx) is one of the major components of the thiol reducing system and plays multiple roles in cellular processes. computational analyses of txnrd1, txnip and trx expressio...

introduction: the gastrin releasing peptide (grp) receptor is over expressed in a variety of common human tumors. radiolabeled bombesin analogues have exhibited high binding affinity for these receptors. the aim of this study was to assess the value of a new 99mtc-bombesin analog in the differentiation of malignant from benign breast tumors. methods: 99mtc-bombesin scans were performed in 21 pa...

background and objective: the dbc2 (deleted in breast cancer 2) or rhobtb2 (located on 8p21) is a tumor suppressor gene associated with tumorigenesis. mutational studies of dbc2 at its promoter region in breast cancer revealed an important role for epigenetic changes contributing to its low expression. epigenetic changes through hypermethylation of the promoter can cause the inactivation of dbc...

background and purpose: after lung cancer, breast cancer, among the prevalent cancers of the world is of the most widespread disease among women. it is the most common cause of mortality among women. this study aimed to analyze the results using breast cancer screening methods among women over 20 years old. materials and methods: the present study is a cross-sectional-descriptive research. the ...