BACKGROUND Exosomal microRNAs (miRNAs) are promising candidate biomarkers for diagnosis or prognosis for breast cancer. We investigated the prognostic role of exosomal miRNAs in serum samples derived from patients with breast cancer and compared miRNA expression between serum and tumor tissues. METHODS The miRNA profile derived from exosome between breast cancer patients with recurrence (n = ...

The incidence of isolated loco-regional recurrence of breast cancer is between 2–20%. It constitutes the most common type of breast cancer recurrence. In contrast to distant metastasis, a number of curative therapies are available to treat isolated loco-regional recurrence of breast cancer. Screening for early detection and regular examinations as part of a recommended follow-up programme is im...

Ductal carcinoma in situ (dcis) is often described as a noninvasive form of breast cancer or a precursor lesion1. This designation is based on the histologic appearance of the lesions and on their typical clinical course. In strict terms, “noninvasive” refers to the absence of visible cancer cells beyond the basement membrane (pathology description of a lesion once it is removed and examined un...

BACKGROUND Distant recurrence is one of the most important risk factors in overall survival, and distant recurrence is related to a complex biologic interaction of seed and soil factors. The aim of the study was to investigate the association between the molecular subtypes and patterns of distant recurrence in patients with breast cancer. METHODS In an investigation of 313 women with breast c...

background: quantification of radiation-induced apoptosis in peripheral blood lymphocytes (pbls) has been proposed as a possible screening test for cancer-prone individuals and also for the prediction of normal tissue responses after radiotherapy. materials and methods: the neutral version of the comet assay (single-cell gel electrophoresis) was used 24, 48, 72 hours after irradiation with 8 gy...