BACKGROUND The expression of HER-2 and Survivin is correlated with poor prognosis of breast cancer, but a possible interaction of these two proteins remains to be established. AIM The aim of this study is to determine the possible relationship between HER-2 and Survivin in primary invasive ductal breast cancer. METHODS Eighty-six patients diagnosed with primary invasive ductal breast cancer...

Abstract Hormone receptor-positive (HR +), HER2 −is the most prevalent metastatic breast cancer subtype, constituting 73.1% of disease population in US. Despite targeted therapies that have increased long-term survival, many patients develop and eventually succumb to disease. Tumor dissemination occurs early during progression is driven by cellular molecular changes tissue. Though host-intrinsi...

This paper presents a 2-D model to calculate the electric current densities and the biopotential differences generated due to a breast cancerous cell during the hyperpolarization of the G1/synthesis (G1/S) transition. The proposed model is based on semiconductor diffusion-drift analysis, and aims to understand the biophysics associated with growing breast cancerous cells. The effect of the dura...

Stokes shift spectroscopy (S3) offers a novel and simpler way to rapidly recognize spectral fingerprints of multiple fluorophores in complex media such as in tissue. This spectroscopic technique can be used as an effective approach to detect cancer in tissue. The alterations of the measured S3 spectra between cancerous and normal tissues were observed in human breast and prostate samples. In or...

IL-10 is an 18-kd polypeptide that has been shown to be secreted by multiple cell types, including T and B cells, monocytes and some human tumors. However, which cell population is responsible for the elevated IL-10 levels in the serum and ascites of ovarian cancer patients, whether ovarian carcinoma cells produce IL-10, and how IL-10 influences the development and progression of ovarian carcin...

Breast cancer is a leading cause of female deaths worldwide. In Malaysia, it is the most common form of female cancer while Infiltrating ductal carcinoma (IDC) is the most common form of breast cancer. A proteomic approach was used to identify changes in the protein profile of breast cancerous and normal tissues. The patients were divided into different cohorts according to tumour stage and gra...

The present work designed and investigated a 3D basic model for breast cancer detection at the ISM band. consists of two multi-slotted rectangular patch antennas three-layer phantom containing tumors. A antenna was 2.45 GHz using CST STUDIO SUITE 2018, where simulated results showed return loss better than -35 dB attended more 77 MHz bandwidth. diagnosis approach is based on exploiting electric...

Obesity is associated with an increased risk of breast cancer. Leptin, a hormone synthesised essentially by adipose tissue, may be involved in cancer development. We examined the expression of leptin and leptin receptor (Ob-R) in human primary breast cancer and adjacent non-cancerous tissue. We also analysed their relationships with histological variables such as the oestrogen and progesterone ...