BACKGROUND Several observational studies have shown that magnetic resonance imaging (MRI) is significantly more sensitive than mammography for screening women over age 25 at high risk for hereditary breast cancer; however, MRI is more costly and less specific than mammography. We sought to determine the extent to which the low sensitivity of mammography is due to greater breast density. METHO...

The insulin-like growth factor (IGF) pathway is believed to play a role in carcinogenesis of the mammary gland. Single nucleotide polymorphisms (SNPs) of IGF-I, IGF-binding protein-3 (IGFBP-3), IGF receptor 1, insulin receptor substrate 1, and phosphoinositide-3-kinase, catalytic, beta polypeptide genes, which are members of the IGF pathway, have been associated with risk of common cancers, bre...

Breast density segmentation and classification methods are combined to enable the automatic and quantitative comparison of temporal mammograms of women using Hormone Replacement Therapy (HRT). The results are based on registration and density quantification, so that potentially the clinician may be informed about substantial localised breast density changes. The measures use texture based densi...

PURPOSE Recently, cone-beam breast computed tomography (CBCT) is established for the breast investigation. The purpose of the present study was to investigate possible associations between CBCT findings and histopathological features in breast cancer. METHODS Overall, 59 female patients, mean age of 64.6 years with histological proven breast cancer were included into the study. In all cases, ...

Little is known about the breast cancer risk factors or mammogram characteristics among Native-American women. Southwestern Native-American women have a low risk of breast cancer and a high risk of diabetes. Our purpose was to determine the prevalence of known clinical risk factors for breast cancer and their association with mammogram density in a sample of Southwestern Native-American women u...

OBJECTIVE To perform a pilot study of the effects on the breast by low-dose intrauterine progestogen combined with estrogen. DESIGN A prospective pilot study. SETTING University hospital. PATIENT(S) Twenty postmenopausal women without any previous breast disorder. INTERVENTION(S) Women were treated with a low-dose intrauterine system releasing 20 microg/24 hours of levonorgestrel in con...

In this issue of the Journal, Ghosh et al. (1) describe the application of two visual assessments to predict breast cancer risk—lobular involution, a histological observation, and mammographic breast density (MBD), a radiological assessment. Previously, this group has demonstrated that more extensive lobular involution was inversely related to both MBD (2) and breast cancer risk (3) in a cohort...

BACKGROUND Evidence accumulates that physical inactivity is one of the few modifiable risk factors for breast cancer. The mechanism through which physical inactivity affects breast cancer risk is not clear. The study aim was to investigate the association between physical activity and breast density because mammographic density is strongly associated with breast cancer risk. METHODS We did a ...

Mammographic density is strongly associated with breast cancer, being considered one of the most important risk indicators for the development of this type of disease. Likewise, the sensitivity of automatic breast lesion detection systems is significantly dependent on breast tissue characteristics. Therefore, the measurement of density is definitely useful for detecting breast cancer. The aim o...

Mediterranean populations' lower breast cancer incidence has been attributed to a traditional Mediterranean diet, but few studies have quantified Mediterranean dietary pattern intake in relation to breast cancer. We examined the association of a Mediterranean diet scale (MDS) with mammographic breast density as a surrogate marker for breast cancer risk. Participants completed a dietary question...