background : st6gal1, cox-2 and hb-egf genes are involved in different tumors and their enhanced expressions often correlate with poor prognosis. in this study we assay the expressions of these genes by reverse transcriptase-pcr in 54 breast cancer samples. methods : tissue samples were either formalin-fixed for histopathological examination or frozen for reverse transcriptase-pcr. image progra...

phyllodes tumors are biphasic fibroepithelial neoplasms of the breast. while the surgical management of these relatively uncommon tumors has been addressed in the literature, few reports have commented on the surgical approach to tumors greater than ten centimetres in diameter – the giant phyllodes tumor. we report a case of giant breast tumors and discuss the techniques utilized for pre-operat...

background: a hemangioma is a rather common benign soft tissue tumor that rarely originates from both the pectoralis muscle and the breast. vascular tumors of the breast, such as benign hemangiomas, are rarely seen in men. case presentation: a 40-year-old man presented with a non-tender palpable right breast mass since 6 months ago. on physical examination, a hard lump was detected in the centr...

metaplastic carcinoma is a rare form of breast cancer and is a generic term for breast carcinoma of ductal type in which the predominant component of the neoplasm has an appearance other than epithelial glandular structures.we report a case of this rare tumor in as 57-year-old psot- menopausal woman

BACKGROUND The surgical approach to breast cancer changed dramatically in the past 20 years. The surgical objective today is to remove the tumor, ensuring negative margins and good cosmetic results, and preserving the breast when possible. Magnetic resonance imaging of the breast has become an essential imaging tool prior to surgery, diagnosing additional tumors and assessing tumor extent. Tumo...

In Vitro Tumor Model article number 2200141, Joaquim M. Oliveira and co-workers show the development of a silk hydrogel-based 3D in vitro breast cancer model. The model highlights importance matrix stiffness cells fibroblasts interaction for tumor progression, which influence chemotherapeutic drug treatment response. developed will allow deeper understanding tumor-stroma interactions, leading t...

dna methylation plays an important role in carcinogenesis through epigenetic silencing of tumor suppressor genes. aberrant methylation usually results from changes in the activity of dna methyltransferases (dnmts). some studies show that the overexpression of the dnmts may lead to aberrant methylation of tumor suppressor genes. also the overexpression of dnmts may be related to methylation stat...

granular cell tumor is a rare benign neoplasm most commonly appears in the head and neck region, especially in the tongue, cheek mucosa, and palate. occurrence in limbs is even rarer. these tumors account for approximately 0.5% of all soft tissue tumors. granular cell tumor can also affect other organs including skin, breast, and lungs. local recurrence and metastasis is potentially higher in m...

Background: Non-coding RNAs apply regulations on expression or function of a gene. A class of non-coding RNAs, natural antisense transcripts, might overlap with their flanking genes and emerge a new complexity upon regulation. WRAP53, is a natural antisense transcript overlapped in a head-to-head manner on the opposite strand of TP53. It has 3 transcripts of which WRAP53β produ...

Cancer Nanovaccines In article number 2104849, Mi Liu and co-workers demonstrate a simple universal method to prepare therapeutic preventive cancer nanovaccines based on tumor tissues/cells. Such show both potent efficacy in lung cancer, melanoma, breast cancer. This can be applied make tumor-cell-based for immunotherapy prevention.