Micronucleus (MN) induction is an established cytogenetic end point for evaluating structural and numerical chromosomal alterations in genotoxicity testing. A semi-automated scoring protocol for the assessment of MN preparations from human cell lines and a 3D skin cell model has been developed and validated. Following exposure to a range of test agents, slides were stained with 4'-6-diamidino-2...

A case of potassium bromate intoxication showing a severe hearing loss and anuria was reported. This 19 years old female patient had no vertigo nor vestibular disorders, but a strong cochlear damage was suspected by electerochleography. In order to investigate the effects of potassium bromate on the inner ear, the authors performed experiments by using guinea pigs. At first, various concentrati...

In the last few years many new reaction routes and intermediates have been discovered in the mechanism of the Belousov-Zhabotinsky (BZ) reaction with the aid of high performance liquid chromatography (HPLC). These previous HPLC studies, however, were limited to the Ce(4+)-organic substrate (malonic or bromomalonic acid) systems only. Very recently some measurements were made on a cerium catalys...

We have previously established an experimental system for oxidative DNA damage-induced tumorigenesis in the small intestine of mice. To elucidate the roles of mismatch repair genes in the tumor suppression, we performed oxidative DNA damage-induced tumorigenesis experiments using Msh2-deficient mice. Oral administration of 0.2% Potassium Bromate, KBrO3, effectively induced epithelial tumors in ...

published in Advance ACS Abstracts, October 1 , 1994. 0022-36541941209810750$04.50/0 autocatalysis rate from the known simple dependence, or whether the pulse amplitude and pulse width start to play a role. In this paper, we present a numerical study of SOW propagation in the BZ reaction-diffusion system to elucidate the problem and find out whether it is possible to separate the effect of the ...

The utility of a cationic polymer polyethylenimines (PEI) for coating some commercially available silica-based stationary phases packed in capillaries of 0.32 mm i.d. and 10 cm long was studied for the separation and direct UV detection of inorganic anions (iodate, bromate, nitrite, bromide, and nitrate ions). With a super-endcapped octadecylated silica stationary phase, which yielded the best...

Chinese hamster ovary cell lines (AA8 and AS52) were stably transfected to overexpress hOgg1 protein, the human DNA repair glycosylase for 7,8-dihydro-8-oxoguanine (8-oxoG). In the transfectants, the repair rate of 8-oxoG residues induced by either potassium bromate or the photosensitizer [R]-1-[(10-chloro-4-oxo-3-phenyl-4H-benzo[a]quinolizin-1-yl)-carbo nyl ]-2-pyrrolidinemethanolplus light wa...

Some years ago, we reported that 3-phenylsydnone underwent dilithiation to yield the dilithio species, upon treatment with n-butyllithium. Subsequent reactions with electrophiles led to variously substituted aryl sydnones, dependent on the nature of the electrophile employed. Sydnonimines, exocyclic nitrogen analogs of sydnones, exhibit interesting biological properties and, accordingly, it was...

Bisphenol A (BPA) is a biologically active industrial chemical used in production of consumer products. BPA has become a target of intense public scrutiny following concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer. Recent studies link BPA with the generation of reactive oxygen species, and base excision repair (BER) is responsible ...

We consider a discrete version of the Brusselator Model of the famous Belousov-Zhabotinsky reaction in chemistry. The original model is a reaction-diffusion equation and its discrete version is a coupled map lattice. We study the dynamics of the local map, which is a smooth map of the plane. We discuss the set of trajectories that escape to infinity as well as analyze the set of bounded traject...