properties and the therapy has been shown to have an acute and sustained beneficial effect on lung function (changes in FEV 1 ) in chronic persistent asthma [6] . Antileukotrienes do not have major side effects and appear to be well tolerated by most patients [7] , but a limitation of their widespread use may be due to the large percentage of nonresponders [8] . However, for those intolerant or...

Objective: The study was done to evaluate the antiasthma activity of Macerated and Soxhlet extracts of (pulp) of plant Liomnia acidissima Linn on tracheal chains of guinea pigs. Methods: The (pulp) of fruits of plant Liomnia acidissima Linn was extracted with 95% ethanol at 55oC and evaluate for their antiasthma activity on tracheal chains of guinea pigs by using three cumulative concentrations...

BACKGROUND Long acting bronchodilators are the standard of care in the management of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the efficacy and safety of V0162, a novel anticholinergic agent with bronchodilator properties, in preclinical models and in patients with COPD. METHODS Guinea pigs were used to evaluate the impact of V0162 on the acetylcho...

BACKGROUND Conventionally, a nebulized short-acting β-2 agonist like salbutamol is often used as the reliever in acute exacerbations of asthma. However, recent worldwide respiratory outbreaks discourage routine use of nebulization. Previous studies have shown that combined budesonide/formoterol (Symbicort®, AstraZeneca) is effective as both a maintenance and reliever anti-asthmatic medication. ...

BACKGROUND The inhaled corticosteroid (ICS) fluticasone propionate (fluticasone) and the long-acting β2-agonist (LABA) formoterol fumarate (formoterol) are being made available as a combination product (fluticasone/formoterol, flutiform ®) in a single aerosol inhaler. This 12-week, open-label, randomized, active-controlled, parallel-group, multicentre, phase 3 study compared the efficacy and sa...

BACKGROUND Long-acting β2-adrenergic agonists (LABAs) are recommended in combination with inhaled corticosteroids (ICSs) for asthma management. Abediterol is a novel, selective, potent, once-daily LABA in development for treatment of asthma and chronic obstructive pulmonary disease. This study aimed to determine abediterol doses with similar peak bronchodilatory effect to salbutamol 400 μg, and...

TOPIC: Allergy and Airway TYPE: Medical Student/Resident Case Reports INTRODUCTION: Severe Asthma Exacerbations (SAE) in opiate tolerant patients merit consideration of non-narcotic sedation strategies. The following case illustrates unique challenges. CASE PRESENTATION: A 24-year-old male with a history asthma presented to our ED for acutely worsening shortness breath one hour. He ran out his ...

Organic anion transporter 2 (Oat2 [SLC22A7]) is a multispecific organic anion transporter. Although several substrates of human Oat2 (hOat2) have been elucidated, a possible involvement of hOat2 in drug interaction is less defined. The purpose of this study was to investigate the interaction of theophylline with erythromycin mediated by hOat2 using a Xenopus laevis oocyte expression system. Whe...

1013 May 2013 I N this current issue of Anesthesiology, Xiang et al.1 describe the effects of volatile anesthetic activation of type A γ-amino butyric acid (GABAA) receptors expressed on airway epithelial cells. It has long been appreciated that a key mechanism in the action of general anesthetics in the brain involves the anesthetics’ allosteric potentiation of GABA on GABAA receptors, thereby...

The introduction of long-acting b2-adrenergic agonists (salmeterol and formoterol) in the early 1990s came at a rather critical moment. Various epidemiological studies had recently demonstrated a relationship between prolonged use of b2-adrenergic agonists and mortality due to asthma [1±5]. These publications did not go unheeded: they triggered intense debate on the possible risks of the use of...